Laboratory studies
Studies in cultured cells and laboratory animals. They test how palmitoylethanolamide might work.
A laboratory study shows a mechanism. It does not show an effect in patients. Doses in a dish are often far above the levels measured in human blood, and results in mice often fail to carry over to people. How to read a study page.
279 studies listed, newest first.
- Palmitoylethanolamide (PEA) regulates cell cycle progression and promotes an anti-inflammatory transcriptomic signature in C2C12 skeletal muscle cellsLaboratory studyOther animals
- The Effects of Palmitoylethanolamide or Ibuprofen on the Abundance Profile and Synthesis Rate of Proteins in C2C12 Skeletal MyotubesLaboratory studyOther animals
- Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of Alzheimer's diseaseLaboratory studyOther animals
- Low-dose combination of ultramicronized palmitoylethanolamide and docosahexaenoic acid on neurosteroid and neuroinflammatory dysregulation in autism spectrum disordersLaboratory studyOther animalsWith docosahexaenoic acid (DHA)
- Sustained Palmitoylethanolamide Infusion Restores Incentive Motivation and Synaptic Plasticity in the Tg2576 Mouse Model of Alzheimer's DiseaseLaboratory studyOther animals
- Synergistic modulation of nociceptive and inflammatory pain by palmitoylethanolamide and Cucumis sativus extract in a monosodium-iodoacetate induced osteoarthritic rat modelLaboratory studyOther animalsWith Cucumis sativus extract (branded Ostizeel)
- Palmitoylethanolamide ameliorates postoperative cognitive dysfunction via microglial PPARα-mediated anti-inflammatory and neuroprotective mechanismsLaboratory studyOther animals
- N-Palmitoylethanolamide enhances antinociceptive effect of tramadol in neuropathic ratsLaboratory studyOther animalsWith tramadol
- Palmitoylethanolamide (PEA) Induces an Increase in Spleen Regulatory T Cells, Reduces CD8 + Cells and TNF-α Levels in Target Organs, and Protects Mice From Graft-Versus-Host Disease-Related Mortality Through PPAR Activation Without Compromising the Graft-Versus-Tumour ResponseLaboratory studyOther animals
- Enhancement of peripheral fatty acyl ethanolamide signaling prevents stress-induced social avoidance and anxiety-like behaviors in male ratsLaboratory studyOther animals
- Evaluation of N-palmitoylethanolamine (PEA) binding to nuclear receptors through docking and molecular dynamics studiesLaboratory studyOther animals
- In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and PalmitoylethanolamideLaboratory studyOther animalsWith Hericium erinaceus, bilberry extract and Centella asiatica
- Time-controlled online SPE: strategic approach for N-acylethanolamines quantification in complex matricesLaboratory studyHorses
- Discovery of a long-acting nanocrystal formulation of INND-2201, a new co-drug of pregabalin and palmitoylethanolamide with synergistic analgesic effectsLaboratory studyOther animalsWith INND-2201 (a co-drug combining pregabalin and PEA, tested as a single conjugate molecule)
- Investigating Hybrid PLGA-Lipid Nanoparticles as an Innovative Delivery Tool for Palmitoylethanolamide to Muscle CellsLaboratory studyOther animals
- Pharmacokinetics of micronized and water dispersible palmitoylethanolamide in comparison with standard palmitoylethanolamide following single oral administration in male Sprague-Dawley ratsLaboratory studyOther animals
- Lipid mediator palmitoylethanolamide (PEA) inhibits pathogenic T cell differentiation in vitro and in vivoLaboratory studyOther animals
- Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer's diseaseLaboratory studyOther animals
- Lactiplantibacillus sp. LP03 alleviates pulmonary fibrosis by modulating gut microbiota and elevating host palmitoylethanolamide to suppress TGF-β1/Smad2/3-mediated EMTLaboratory studyOther animals
- A Sensitive Ultrahigh-Performance Liquid Chromatography/Tandem Mass Spectrometry Method for the Simultaneous Analysis of Phytocannabinoids and Endocannabinoids in Plasma and BrainLaboratory studyOther animals
- Palmitoylethanolamide causes dose-dependent changes in brain function and the lipidomeLaboratory studyOther animals
- Oleoylethanolamide and Palmitoylethanolamide Enhance IFNβ-Induced Apoptosis in Human Neuroblastoma SH-SY5Y CellsLaboratory studyHumansWith interferon beta (co-exposure); oleoylethanolamide tested in parallel
- PEA-OXA restores cognitive impairments associated with vitamin D deficiency-dependent alterations of the gut microbiotaLaboratory studyOther animalsWith PEA-OXA (2-pentadecyl-2-oxazoline, a PEA analogue, tested alone)
- Nutraceutical formulation based on a synergic combination of melatonin and palmitoylethanolamide for the management of allergic eventsLaboratory studyHumansWith melatonin
- Inflammatory-Targeted Lipid Carrier as a New Nanomaterial to Formulate an Inhaled Drug Delivery SystemLaboratory studyOther animals
- New insights in the mechanisms of opioid analgesia and tolerance: Ultramicronized palmitoylethanolamide down-modulates vascular endothelial growth factor-A in the nervous systemLaboratory studyOther animalsWith morphine
- Ultramicronized N-palmitoylethanolamine Contributes to Morphine Efficacy Against Neuropathic Pain: Implication of Mast Cells and GliaLaboratory studyOther animalsWith morphine
- Palmitoylethanolamide-Incorporated Elastic Nano-Liposomes for Enhanced Transdermal Delivery and Anti-InflammationLaboratory studyHumansOther animalsTopical
- Prevention of Protease-Induced Degradation of Desmoplakin via Small Molecule BindingLaboratory studyOther animals
- Palmitoylethanolamide (PEA) for Prevention of Gastroesophageal Inflammation: Insights from In Vitro ModelsLaboratory studyHumansWith Zingiber officinale, Musa × paradisiaca, Opuntia ficus-indica and Olea europaea plant extracts
- Amelioration of Dextran Sodium Sulfate-Induced Colitis in Mice through Oral Administration of PalmitoylethanolamideLaboratory studyOther animals
- N-palmitoylethanolamide attenuates negative emotions induced by morphine withdrawal in miceLaboratory studyOther animals
- Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathwayLaboratory studyOther animalsWith adelmidrol (a PEA analogue, tested alone)
- Lysosome targeting fluorescent probe for NAAA imaging and its applications in the drug development for anti-inflammatoryLaboratory studyOther animals
- Genetic Knockout of Fatty Acid Amide Hydrolase Ameliorates Cisplatin-Induced Nephropathy in MiceLaboratory studyOther animalsHumans
- N-palmitoylethanolamide synergizes the antinociception of morphine and gabapentin in the formalin test in miceLaboratory studyOther animalsWith morphine and gabapentin (each tested separately in combination with palmitoylethanolamide)
- Effect of palmitoylethanolamide on degeneration of a human-derived retinal pigment epithelial cell induced by all-trans retinalLaboratory studyHumansOther animals
- Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamideLaboratory studyOther animals
- G protein-coupled receptor 55 activated by palmitoylethanolamide is associated with the development of nocturia associated with circadian rhythm disordersLaboratory studyOther animals
- Ramulus Cinnamomi essential oil exerts an anti-inflammatory effect on RAW264.7 cells through N-acylethanolamine acid amidase inhibitionLaboratory studyHumansOther animals
- Optimization of Fermentation Conditions and Metabolite Profiling of Grape Juice Fermented with Lactic Acid Bacteria for Improved Flavor and BioactivityLaboratory studyOther animals
- Inhibiting immunoregulatory amidase NAAA blocks ZIKV maturation in Human Neural Stem CellsLaboratory studyHumans
- Palmitoylethanolamide shows limited efficacy in controlling cerebral cryptococcosis in vivoLaboratory studyOther animalsWith amphotericin B (in one arm; palmitoylethanolamide also tested alone)
- Activation of cannabinoid type 1 receptor (CB1) modulates oligodendroglial process branching complexity in rat hippocampal cultures stimulated by olfactory ensheathing glia-conditioned mediumLaboratory studyOther animals
- Intrarectal Administration of Adelmidrol plus Hyaluronic Acid Gel Ameliorates Experimental Colitis in Mice and Inhibits Pro-Inflammatory Response in Ex Vivo Cultured Biopsies Derived from Ulcerative Colitis-Affected PatientsLaboratory studyHumansOther animalsWith adelmidrol (a PEA analogue) with hyaluronic acid, as a gel
- Palmitoylethanolamide counteracts high-fat diet-induced gut dysfunction by reprogramming microbiota composition and affecting tryptophan metabolismLaboratory studyOther animals
- Exploring the Protective Effect against 7,12-Dimethylbenz[a]anthracene-Induced Breast Tumors of PalmitoylethanolamideLaboratory studyOther animals
- Isolation and characterization of N-(2-Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis-inducing potential in breast cancer cellsLaboratory studyHumans
- Novel Approach to the Treatment of Neuropathic Pain Using a Combination with Palmitoylethanolamide and Equisetum arvense L. in an In Vitro StudyLaboratory studyOther animalsWith Equisetum arvense L. (horsetail) extract
- In Vitro and In Vivo Safety of Hyaluronic Acid-Decorated Microparticles for Intravitreal Injection of Palmitoylethanolamide, Citicoline, or Glial-Cell-Derived Neurotrophic FactorLaboratory studyHumansOther animals
- Sphingosine Kinases at the Intersection of Pro-Inflammatory LPS and Anti-Inflammatory Endocannabinoid Signaling in BV2 Mouse Microglia CellsLaboratory studyOther animals
- Distribution of an analgesic palmitoylethanolamide and other N-acylethanolamines in human placental membranesLaboratory studyHumans
- Micronized Palmitoylethanolamide, Hempseed Oil, and Maritime Pine Bark Dry Extract (Pelvipea®) for Pelvic Pain: An In Vitro Study for Urothelial Inflammation TreatmentLaboratory studyHumansWith hempseed oil and maritime pine bark dry extract (combined as Pelvipea)
- Labour and premature delivery differentially affect the expression of the endocannabinoid system in the human placentaLaboratory studyHumans
- Ultramicronized N-Palmitoylethanolamine Regulates Mast Cell-Astrocyte Crosstalk: A New Potential Mechanism Underlying the Inhibition of Morphine ToleranceLaboratory studyOther animals
- Assay of NAAA ActivityLaboratory studyOther animals
- A Combination of α-Lipoic Acid (ALA) and Palmitoylethanolamide (PEA) Blocks Endotoxin-Induced Oxidative Stress and Cytokine Storm: A Possible Intervention for COVID-19Laboratory studyHumansWith alpha-lipoic acid
- Quantification of Analgesic and Anti-Inflammatory Lipid Mediators in Long-Term Cryopreserved and Freeze-Dried Preserved Human Amniotic MembraneLaboratory studyHumans
- Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by MacrophagesLaboratory studyOther animals
- N-palmitoylethanolamine modulates hippocampal neuroplasticity in rats with stress-induced depressive behavior phenotypeLaboratory studyOther animals
- Melatonin synergizes with the antinociceptive effect of N-palmitoylethanolamide and paracetamolLaboratory studyOther animalsWith melatonin and paracetamol
- Palmitoylethanolamide Promotes White-to-Beige Conversion and Metabolic Reprogramming of Adipocytes: Contribution of PPAR-αLaboratory studyHumansOther animals
- Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission: An Integrated Approach in a Triple Transgenic Mouse Model of Alzheimer's DiseaseLaboratory studyOther animals
- Inhibition of triple negative breast cancer-associated inflammation and progression by N- acylethanolamine acid amide hydrolase (NAAA)Laboratory studyHumansOther animals
- Antioxidant and Anti-Inflammatory Activity of Combined Phycocyanin and Palmitoylethanolamide in Human Lung and Prostate Epithelial CellsLaboratory studyHumansWith phycocyanin
- Lipidomics of Cell Secretome Combined with the Study of Selected Bioactive Lipids in an In Vitro Model of OsteoarthritisLaboratory studyHumans
- Distribution of Cannabinoid Receptors in Keratinocytes of Healthy Dogs and Dogs With Atopic DermatitisLaboratory studyDogs
- The Beneficial Effects of Ultramicronized Palmitoylethanolamide in the Management of Neuropathic Pain and Associated Mood Disorders Induced by Paclitaxel in MiceLaboratory studyOther animals
- Oral Adelmidrol Administration Up-Regulates Palmitoylethanolamide Production in Mice Colon and Duodenum through a PPAR-γ Independent ActionLaboratory studyOther animalsWith adelmidrol (a PEA analogue, tested alone)
- Intestinal Disorder in Zebrafish Larvae (Danio rerio): The Protective Action of N-Palmitoylethanolamide-oxazolineLaboratory studyOther animalsWith N-palmitoylethanolamide-oxazoline (PEA-OXA, a PEA analogue, tested alone)
- Central GPR55 may prevent nicotine reinforcing actions: a preliminary studyLaboratory studyOther animals
- Palmitoylethanolamide Mitigates Paclitaxel Toxicity in Primary Dorsal Root Ganglion NeuronsLaboratory studyOther animals
- Co-Ultramicronized Palmitoylethanolamide/Luteolin Restores Oligodendrocyte Homeostasis via Peroxisome Proliferator-Activated Receptor-α in an In Vitro Model of Alzheimer's DiseaseLaboratory studyOther animalsWith luteolin (co-ultramicronised with palmitoylethanolamide, PEALut)
- Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 ReceptorLaboratory studyHumans
- α-Acylamino-β-lactone N-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors Encapsulated in PLGA Nanoparticles: Improvement of the Physical Stability and Protection of Human Cells from Hydrogen Peroxide-Induced Oxidative StressLaboratory studyHumansWith URB866 (a NAAA inhibitor that raises the body's own palmitoylethanolamide), loaded in PLGA nanoparticles; PEA itself was not given
- Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in ratsLaboratory studyOther animals
- Effects of fatty acid metabolites on nocturiaLaboratory studyOther animals
- MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microgliaLaboratory studyOther animalsHumansWith luteolin (co-ultramicronised PEA plus luteolin, PEALut)
- Aerosol-Administered Adelmidrol Attenuates Lung Inflammation in a Murine Model of Acute Lung InjuryLaboratory studyOther animalsWith adelmidrol (a PEA analogue, tested alone)
- Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese miceLaboratory studyOther animals
- N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturationLaboratory studyHumansOther animals
- The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male ratsLaboratory studyOther animalsWith ARN15381 (a FAAH inhibitor and D3 partial agonist), URB597 and CJB090; palmitoylethanolamide itself was not given
- Synergistic antinociceptive effects of concomitant NAAA and peripheral FAAH inhibitionLaboratory studyOther animalsWith URB937 (a peripheral FAAH inhibitor) and ARN19702 (a NAAA inhibitor), enzyme inhibitors that raise the body's own palmitoylethanolamide and anandamide; PEA itself was not given
- Design, Characterization, and In Vitro Assays on Muscle Cells of Endocannabinoid-like Molecule Loaded Lipid Nanoparticles for a Therapeutic Anti-Inflammatory Approach to SarcopeniaLaboratory studyOther animals
- Profound Modification of Fatty Acid Profile and Endocannabinoid-Related Mediators in PPARα Agonist Fenofibrate-Treated MiceLaboratory studyOther animals
- Comprehensive lipidomics of lupus-prone mice using LC-MS/MS identifies the reduction of palmitoylethanolamide that suppresses TLR9-mediated inflammationLaboratory studyOther animals
- Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of parkinsonismLaboratory studyHumansOther animalsWith NAAA gene deletion or NAAA inhibitors, which raise the body's own palmitoylethanolamide; PEA itself was not given
- Anti-inflammatory Effect of Cannabidiol and Palmitoylethanolamide Containing Topical Formulation on Skin in a 12-O-Tetradecanoylphorbol-13-Acetate-Induced Dermatitis Model in MiceLaboratory studyOther animalsTopicalWith cannabidiol
- First Evidence of the Protective Effects of 2-Pentadecyl-2-Oxazoline (PEA-OXA) in In Vitro Models of Acute Lung InjuryLaboratory studyHumansWith PEA-OXA (2-pentadecyl-2-oxazoline, a PEA analogue, tested alongside ultramicronised PEA)
- Palmitoylethanolamide gels edible oilsLaboratory studyOther animals
- Effects of Gabexate Mesylate on the Gut Microbiota and Metabolomics in Rats with SepsisLaboratory studyOther animals
- Novel Drug Candidate Prediction for Intrahepatic Cholangiocarcinoma via Hub Gene Network Analysis and Connectivity MappingLaboratory studyHumans
- Genetic Blockade of NAAA Cell-specifically Regulates Fatty Acid Ethanolamides (FAEs) Metabolism and Inflammatory ResponsesLaboratory studyOther animalsWith NAAA gene deletion (CRISPR-Cas9) or the NAAA inhibitor F96, which raise the body's own palmitoylethanolamide; PEA itself was not given
- Modulation of type 1 cannabinoid receptor activity by cannabinoid by-products from Cannabis sativa and non-cannabis phytomoleculesLaboratory studyOther animals
- Palmitoylethanolamide ameliorates neuroinflammation via modulating PPAR-α to promote the functional outcome after intracerebral hemorrhageLaboratory studyOther animals
- Vitamin D Deficiency Induces Chronic Pain and Microglial Phenotypic Changes in MiceLaboratory studyOther animals
- The Nutraceutical N-Palmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine VaricoceleLaboratory studyOther animals
- Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory PainLaboratory studyOther animalsWith acetyl-L-carnitine
- PEA-OXA Mitigates Oxaliplatin-Induced Painful Neuropathy through NF-κB/Nrf-2 AxisLaboratory studyOther animalsWith PEA-OXA (2-pentadecyl-2-oxazoline, a PEA analogue, tested alongside ultramicronised PEA)
- Co-Ultra PEALut Enhances Endogenous Repair Response Following Moderate Traumatic Brain InjuryLaboratory studyHumansOther animalsWith luteolin (co-ultramicronised PEA plus luteolin, Glialia)
- N-Acylethanolamine Acid Amidase Inhibition Potentiates Morphine Analgesia and Delays the Development of ToleranceLaboratory studyOther animalsWith AM11095 (a brain-permeable NAAA inhibitor that raises the body's own palmitoylethanolamide) given with morphine; PEA itself was not given
- Palmitoylethanolamide Modulation of Microglia Activation: Characterization of Mechanisms of Action and Implication for Its Neuroprotective EffectsLaboratory studyOther animals
- Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular CoagulationLaboratory studyOther animals
- Palmitoylethanolamide/Baicalein Regulates the Androgen Receptor Signaling and NF-κB/Nrf2 Pathways in Benign Prostatic HyperplasiaLaboratory studyOther animalsWith baicalein
- Palmitoylethanolamide Counteracts Enteric Inflammation and Bowel Motor Dysfunctions in a Mouse Model of Alzheimer's DiseaseLaboratory studyOther animals
- Ultramicronized Palmitoylethanolamide Inhibits NLRP3 Inflammasome Expression and Pro-Inflammatory Response Activated by SARS-CoV-2 Spike Protein in Cultured Murine Alveolar MacrophagesLaboratory studyOther animals
- Palmitoylethanolamide: Prenatal Developmental Toxicity Study in RatsLaboratory studyOther animals
- Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral AdministrationLaboratory studyHumansOther animals
- A Palmitoylethanolamide Producing Lactobacillus paracasei Improves Clostridium difficile Toxin A-Induced ColitisLaboratory studyOther animals
- Engineered Lactobacillus paracasei Producing Palmitoylethanolamide (PEA) Prevents Colitis in MiceLaboratory studyOther animals
- Co-Ultramicronized Palmitoylethanolamide/Luteolin-Induced Oligodendrocyte Precursor Cell Differentiation is Associated With Tyro3 Receptor UpregulationLaboratory studyOther animalsWith luteolin (co-ultramicronised PEA/luteolin, PEALut)
- N-acylethanolamine regulation of TLR3-induced hyperthermia and neuroinflammatory gene expression: A role for PPARαLaboratory studyOther animals
- NAAA-regulated lipid signaling governs the transition from acute to chronic painLaboratory studyOther animalsWith Small-molecule NAAA inhibitors, which raise the body's own palmitoylethanolamide; PEA itself was not given
- Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal ModelsLaboratory studyOther animals
- N-acylethanolamine acid amidase (NAAA) inhibition decreases the motivation for alcohol in Marchigian Sardinian alcohol-preferring ratsLaboratory studyOther animalsWith ARN19702, ARN077 and ARN726 (NAAA inhibitors that raise endogenous PEA and OEA, tested alone)
- Micro Composite Palmitoylethanolamide/Rutin Reduces Vascular Injury through Modulation of the Nrf2/HO-1 and NF-kB PathwaysLaboratory studyOther animalsWith rutin
- Pharmacological Blockade of PPARα Exacerbates Inflammatory Pain-Related Impairment of Spatial Memory in RatsLaboratory studyOther animals
- Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidaseLaboratory studyOther animals
- Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraineLaboratory studyOther animalsWith URB937 (a FAAH inhibitor that raises endogenous PEA and anandamide, tested alone)
- Involvement of the γ Isoform of cPLA2 in the Biosynthesis of Bioactive N- AcylethanolaminesLaboratory studyOther animals
- Micronized Palmitoylethanolamide Ameliorates Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis via Inhibiting Inflammation and Restoring AutophagyLaboratory studyOther animals
- Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate in Sprague-Dawley ratsLaboratory studyOther animals
- PEA prevented early BBB disruption after cerebral ischaemic/reperfusion (I/R) injury through regulation of ROCK/MLC signalingLaboratory studyOther animals
- Palmitoylethanolamide counteracts brain fog improving depressive-like behaviour in obese mice: Possible role of synaptic plasticity and neurogenesisLaboratory studyOther animals
- NAAA inhibitor F96 attenuates BBB disruption and secondary injury after traumatic brain injury (TBI)Laboratory studyOther animalsWith F96 (a NAAA inhibitor that raises the body's own palmitoylethanolamide); PEA itself was not given
- Palmitoylethanolamide (PEA) reduces postoperative adhesions after experimental strabismus surgery in rabbits by suppressing canonical and non-canonical TGFβ signaling through PPARαLaboratory studyOther animals
- Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic painLaboratory studyOther animalsWith hemp oil extract
- Design and Structure-Activity Relationships of Isothiocyanates as Potent and Selective N-Acylethanolamine-Hydrolyzing Acid Amidase InhibitorsLaboratory studyHumansOther animals
- A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential BioregulatorLaboratory studyOther animalsWith GLUPEA (a glucuronic acid-PEA conjugate prodrug, tested against ultramicronised PEA)
- In vivo brain levels of acetylcholine and 5-hydroxytryptamine after oleoylethanolamide or palmitoylethanolamide administrations are mediated by PPARα engagementLaboratory studyOther animals
- Different Dietary N-3 Polyunsaturated Fatty Acid Formulations Distinctively Modify Tissue Fatty Acid and N-Acylethanolamine ProfilesLaboratory studyOther animals
- Palmitoylethanolamide Reduces Colon Cancer Cell Proliferation and Migration, Influences Tumor Cell Cycle and Exerts In Vivo Chemopreventive EffectsLaboratory studyHumansOther animals
- NAPE-specific phospholipase D regulates LRRK2 association with neuronal membranesLaboratory studyHumansOther animals
- Management of Acute Lung Injury: Palmitoylethanolamide as a New ApproachLaboratory studyOther animals
- PEA/Polydatin: Anti-Inflammatory and Antioxidant Approach to Counteract DNBS-Induced ColitisLaboratory studyOther animalsWith polydatin (comicronised with ultramicronised PEA)
- Impaired Duodenal Palmitoylethanolamide Release Underlies Acid-Induced Mast Cell Activation in Functional DyspepsiaLaboratory studyHumansOther animals
- Genetically-targeted photorelease of endocannabinoids enables optical control of GPR55 in pancreatic β-cellsLaboratory studyOther animals
- N-acylethanolamine-hydrolysing acid amidase: A new potential target to treat paclitaxel-induced neuropathyLaboratory studyOther animals
- Involvement of acid ceramidase in the degradation of bioactive N-acylethanolaminesLaboratory studyHumansOther animals
- PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathwayLaboratory studyOther animals
- Palmitoylethanolamide counteracts hepatic metabolic inflexibility modulating mitochondrial function and efficiency in diet-induced obese miceLaboratory studyHumansOther animals
- Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependentLaboratory studyOther animalsWith AM6545 (a peripheral CB1 receptor blocker, tested alone)
- Chronic Oral Palmitoylethanolamide Administration Rescues Cognitive Deficit and Reduces Neuroinflammation, Oxidative Stress, and Glutamate Levels in A Transgenic Murine Model of Alzheimer's DiseaseLaboratory studyOther animals
- Astrocytic palmitoylethanolamide pre-exposure exerts neuroprotective effects in astrocyte-neuron co-cultures from a triple transgenic mouse model of Alzheimer's diseaseLaboratory studyOther animals
- Chronic Psychosocial Stress Causes Increased Anxiety-Like Behavior and Alters Endocannabinoid Levels in the Brain of C57Bl/6J MiceLaboratory studyOther animals
- Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH InhibitorsLaboratory studyOther animals
- Essential fatty acids deficient diet modulates N-Acylethanolamide profile in rat's tissuesLaboratory studyOther animals
- Synergic Therapeutic Potential of PEA-Um Treatment and NAAA Enzyme Silencing In the Management of NeuroinflammationLaboratory studyHumansOther animals
- Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of ratsLaboratory studyOther animals
- N-Palmitoylethanolamine Maintains Local Lipid Homeostasis to Relieve Sleep Deprivation-Induced Dry Eye SyndromeLaboratory studyOther animals
- Effect of N-palmitoylethanolamine-oxazoline on comorbid neuropsychiatric disturbance associated with inflammatory bowel diseaseLaboratory studyOther animalsWith PEA-OXA (a PEA analogue, tested alone)
- Synthesis, Molecular Modeling and Biological Evaluation of Metabolically Stable Analogues of the Endogenous Fatty Acid Amide PalmitoylethanolamideLaboratory studyHumansOther animalsWith RePEA (a PEA analogue, tested alone and against PEA)
- Protective effects of Colomast®, A New Formulation of Adelmidrol and Sodium Hyaluronate, in A Mouse Model of Acute Restraint StressLaboratory studyOther animalsWith adelmidrol (a PEA analogue) with sodium hyaluronate (Colomast)
- Fatty Acid Amides Synthesized from Andiroba Oil (Carapa guianensis Aublet.) Exhibit Anticonvulsant Action with Modulation on GABA-A Receptor in Mice: A Putative Therapeutic OptionLaboratory studyOther animalsWith fatty acid amides FAA1 and FAA2 synthesised from andiroba oil (tested alone; not palmitoylethanolamide itself)
- Looking for a Treatment for the Early Stage of Alzheimer's Disease: Preclinical Evidence with Co-Ultramicronized Palmitoylethanolamide and LuteolinLaboratory studyOther animalsWith luteolin (co-ultramicronised PEA/luteolin, PEALut)
- Inhibition of fatty acid amide hydrolase in the CNS prevents and reverses morphine tolerance in male and female miceLaboratory studyOther animalsWith URB597 and URB937 (FAAH inhibitors, tested alone), with morphine
- Adelmidrol: A New Promising Antioxidant and Anti-Inflammatory Therapeutic Tool in Pulmonary FibrosisLaboratory studyOther animalsWith adelmidrol (a PEA analogue, tested alone)
- Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark MiceLaboratory studyOther animals
- Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic painLaboratory studyOther animals
- Night Migratory Songbirds Exhibit Metabolic Ability to Support High Aerobic Capacity during MigrationLaboratory studyOther animals
- Pyridostigmine bromide exposure creates chronic, underlying neuroimmune disruption in the gastrointestinal tract and brain that alters responses to palmitoylethanolamide in a mouse model of Gulf War IllnessLaboratory studyOther animals
- Analogous modulation of inflammatory responses by the endocannabinoid system in periodontal ligament cells and microgliaLaboratory studyHumansOther animals
- Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis VulgarisLaboratory studyHumansWith cannabidiol (tested alone; PEA was a measured lipid)
- Anti-Inflammatory Effects of Fucoxanthinol in LPS-Induced RAW264.7 Cells through the NAAA-PEA PathwayLaboratory studyOther animalsWith fucoxanthinol (a seaweed carotenoid that inhibits NAAA and raises cellular PEA, tested alone)
- Effect of Hataedock Treatment on Epidermal Structure Maintenance through Intervention in the Endocannabinoid SystemLaboratory studyOther animalsWith Douchi (fermented soybean) extract used as Hataedock; genistein and PEA compared in a separate involucrin assay
- ASP8477, a fatty acid amide hydrolase inhibitor, exerts analgesic effects in rat models of neuropathic and dysfunctional painLaboratory studyOther animalsWith ASP8477 (a FAAH inhibitor that raises brain PEA and OEA, tested alone)
- The anti-inflammatory and immune-modulatory effects of OEA limit DSS-induced colitis in miceLaboratory studyOther animalsWith oleoylethanolamide (OEA, a related lipid, tested alone; PEA was not given)
- Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitorsLaboratory studyHumansOther animals
- Potential Mechanisms Involved in Palmitoylethanolamide-Induced Vasodepressor Effects in RatsLaboratory studyOther animals
- A New Palmitoylethanolamide Form Combined with Antioxidant Molecules to Improve Its Effectivess on Neuronal AgingLaboratory studyOther animalsWith lipoic acid and vitamin D3 (tested with a proprietary PEA formulation, FM-LipoMatrix)
- N-Acylethanolamine Acid Amidase contributes to disease progression in a mouse model of multiple sclerosisLaboratory studyOther animals
- Ocular Formulation Based on Palmitoylethanolamide-Loaded Nanostructured Lipid Carriers: Technological and Pharmacological ProfileLaboratory studyOther animalsTopical
- The Protective Effects of Pre- and Post-Administration of Micronized Palmitoylethanolamide Formulation on Postoperative Pain in RatsLaboratory studyOther animals
- Peripheral deficiency and antiallodynic effects of 2-arachidonoyl glycerol in a mouse model of paclitaxel-induced neuropathic painLaboratory studyOther animalsWith 2-arachidonoyl glycerol and JZL184 (a MAGL inhibitor), tested alone; PEA was a measured lipid
- Partial Reversal of Striatal Damage by Palmitoylethanolamide Administration Following Perinatal AsphyxiaLaboratory studyOther animals
- Natural Potent NAAA Inhibitor Atractylodin Counteracts LPS-Induced Microglial ActivationLaboratory studyOther animalsWith atractylodin (a NAAA inhibitor that raises cellular PEA, tested alone)
- PPARα-Dependent Effects of Palmitoylethanolamide Against Retinal Neovascularization and FibrosisLaboratory studyOther animals
- Joint Synovial Fluid Metabolomics Method to Decipher the Metabolic Mechanisms of Adjuvant Arthritis and Geniposide InterventionLaboratory studyOther animalsWith geniposide (tested alone; PEA was a measured metabolite)
- Role of pannexin-1 in the cellular uptake, release and hydrolysis of anandamide by T84 colon cancer cellsLaboratory studyHumans
- Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compoundLaboratory studyOther animals
- Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathwayLaboratory studyOther animals
- Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic PainLaboratory studyOther animals
- Cocaine-Induced Reinstatement of Cocaine Seeking Provokes Changes in the Endocannabinoid and N-Acylethanolamine Levels in Rat Brain StructuresLaboratory studyOther animals
- Impaired brain endocannabinoid tone in the activity-based model of anorexia nervosaLaboratory studyOther animals
- A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitisLaboratory studyOther animalsWith luteolin (co-ultramicronised PEA/luteolin, PEALut)
- Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis painLaboratory studyOther animalsWith N-palmitoyl-D-glucosamine (a related ALIAmide, not PEA, tested alone in plain and micronised forms)
- Effects of a new compound containing Palmitoylethanolamide and Baicalein in myocardial ischaemia/reperfusion injury in vivoLaboratory studyOther animalsWith baicalein
- Food database of N-acyl-phosphatidylethanolamines, N-acylethanolamines and endocannabinoids and daily intake from a Western, a Mediterranean and a vegetarian dietLaboratory studyOther animals
- Formation of HETE-EAs and dihydroxy derivatives in mouse kidney tissue and analysis by high-performance liquid chromatography tandem mass spectrometryLaboratory studyOther animals
- Efficacy of a Combination of N-Palmitoylethanolamide, Beta-Caryophyllene, Carnosic Acid, and Myrrh Extract on Chronic Neuropathic Pain: A Preclinical StudyLaboratory studyOther animalsWith beta-caryophyllene, carnosic acid and myrrh extract (a commercial combination product, Noxiall)
- N-Palmitoylethanolamide-Oxazoline Protects against Middle Cerebral Artery Occlusion Injury in Diabetic Rats by Regulating the SIRT1 PathwayLaboratory studyOther animalsWith PEA-OXA (2-pentadecyl-2-oxazoline, a PEA analogue, tested alone)
- First evidence on the role of palmitoylethanolamide in energy homeostasis in fishLaboratory studyOther animals
- Diurnal Profiles of N-Acylethanolamines in Goldfish Brain and Gastrointestinal Tract: Possible Role of FeedingLaboratory studyOther animals
- Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma - LC-MS/MS method validation and pre-analytical characteristicsLaboratory studyHumans
- Opposite Effects of Neuroprotective Cannabinoids, Palmitoylethanolamide, and 2-Arachidonoylglycerol on Function and Morphology of MicrogliaLaboratory studyOther animalsWith 2-arachidonoylglycerol (2-AG, tested alongside PEA, not as a fixed combination product)
- The neuroprotective effects of micronized PEA (PEA-m) formulation on diabetic peripheral neuropathy in miceLaboratory studyOther animals
- Broad Lipidomic and Transcriptional Changes of Prophylactic PEA Administration in Adult MiceLaboratory studyOther animals
- N-Palmitoylethanolamide Exerts Antidepressant-Like Effects in Rats: Involvement of PPAR α Pathway in the HippocampusLaboratory studyOther animals
- Stimulation of Peroxisome Proliferator-Activated Receptor-α by N-Palmitoylethanolamine Engages Allopregnanolone Biosynthesis to Modulate Emotional BehaviorLaboratory studyOther animals
- Intracellular Ca2+-dependent formation of N-acyl-phosphatidylethanolamines by human cytosolic phospholipase A2εLaboratory studyHumans
- Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague-Dawley ratsLaboratory studyOther animals
- Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activityLaboratory studyOther animals
- The ventral pallidum as a critical region for fatty acid amide hydrolase inhibition of nausea-induced conditioned gaping in male Sprague-Dawley ratsLaboratory studyOther animals
- Endocannabinoid and N-acylethanolamide levels in rat brain and spinal cord following systemic dipyrone and paracetamol administrationLaboratory studyOther animals
- Manganese affects the growth and metabolism of Ganoderma lucidum based on LC-MS analysisLaboratory studyOther animals
- N-Acylethanolamine acid amidase (NAAA) inhibitor F215 as a novel therapeutic agent for osteoarthritisLaboratory studyOther animals
- Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responsesLaboratory studyOther animals
- Micronized palmitoylethanolamide reduces joint pain and glial cell activationLaboratory studyOther animals
- Palmitoylethanolamide Blunts Amyloid-β42-Induced Astrocyte Activation and Improves Neuronal Survival in Primary Mouse Cortical Astrocyte-Neuron Co-CulturesLaboratory studyOther animals
- Palmitoylethanolamide counteracts autistic-like behaviours in BTBR T+tf/J mice: Contribution of central and peripheral mechanismsLaboratory studyOther animals
- N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged MiceLaboratory studyOther animals
- Localization of cannabinoid receptors CB1, CB2, GPR55, and PPAR-alpha in the canine gastrointestinal tractLaboratory studyDogs
- Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial MeningitisLaboratory studyOther animals
- Palmitoylethanolamide Ameliorates Hippocampal Damage and Behavioral Dysfunction After Perinatal Asphyxia in the Immature Rat BrainLaboratory studyOther animals
- Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemiaLaboratory studyOther animals
- Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in RatsLaboratory studyOther animals
- Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic EffectLaboratory studyOther animals
- Oleoylethanolamide and Palmitoylethanolamide Protect Cultured Cortical Neurons Against HypoxiaLaboratory studyOther animalsWith RN1734 (a TRPV4 antagonist), co-treated with PEA in some experiments; oleoylethanolamide (OEA) tested alongside PEA
- Antiepileptogenic Effect of Subchronic Palmitoylethanolamide Treatment in a Mouse Model of Acute EpilepsyLaboratory studyOther animals
- Innovative Nanoparticles Enhance N-Palmitoylethanolamide Intraocular DeliveryLaboratory studyOther animalsTopical
- HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric gliaLaboratory studyOther animals
- Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer's disease by exerting anti-inflammatory and neuroprotective effectsLaboratory studyOther animals
- Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in miceLaboratory studyOther animals
- Synthesis, biological evaluation, and structure activity relationship (SAR) study of pyrrolidine amide derivatives as N-acylethanolamine acid amidase (NAAA) inhibitorsLaboratory studyOther animals
- Ultramicronized palmitoylethanolamide counteracts the effects of compound 48/80 in a canine skin organ culture modelLaboratory studyDogs
- Identification of a Widespread Palmitoylethanolamide Contamination in Standard Laboratory GlasswareLaboratory studyOther animals
- A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain modelsLaboratory studyOther animalsWith quercetin
- Effects of a co-micronized composite containing palmitoylethanolamide and polydatin in an experimental model of benign prostatic hyperplasiaLaboratory studyOther animalsWith polydatin
- Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colonLaboratory studyHumans
- The anti-inflammatory compound palmitoylethanolamide inhibits prostaglandin and hydroxyeicosatetraenoic acid production by a macrophage cell lineLaboratory studyOther animals
- Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injuryLaboratory studyOther animalsWith polydatin
- Palmitoylethanolamide Reduces Neuropsychiatric Behaviors by Restoring Cortical Electrophysiological Activity in a Mouse Model of Mild Traumatic Brain InjuryLaboratory studyOther animals
- Palmitoylethanolamide Modulates GPR55 Receptor Signaling in the Ventral Hippocampus to Regulate Mesolimbic Dopamine Activity, Social Interaction, and Memory ProcessingLaboratory studyOther animals
- Relationship Between Circulating Fatty Acids and Fatty Acid Ethanolamide Levels After a Single 2-h Dietary Fat Feeding in Male Sprague-Dawley Rats : Elevated levels of oleoylethanolamide, palmitoylethanolamide, linoleoylethanolamide, arachidonoylethanolamide and docosahexanoylethanolamide after a single 2 h dietary fat feeding in male Sprague Dawley ratsLaboratory studyOther animals
- Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the MouseLaboratory studyOther animals
- Effect of palmitoylethanolamide on inflammatory and neuropathic pain in ratsLaboratory studyOther animals
- Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stress: In vivo and in vitro evidenceLaboratory studyHumansOther animals
- A novel protective formulation of Palmitoylethanolamide in experimental model of contrast agent induced nephropathyLaboratory studyOther animals
- Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel DiseaseLaboratory studyOther animalsWith adelmidrol (a PEA analogue, tested alone)
- Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord InjuryLaboratory studyOther animalsWith luteolin
- Protective Effects of Ultramicronized Palmitoylethanolamide (PEA-um) in Myocardial Ischaemia and Reperfusion Injury in VIVOLaboratory studyOther animals
- Co-micronized Palmitoylethanolamide/Polydatin Treatment Causes Endometriotic Lesion Regression in a Rodent Model of Surgically Induced EndometriosisLaboratory studyOther animalsWith polydatin
- Ultramicronized palmitoylethanolamide (PEA-um(®)) in the treatment of idiopathic pulmonary fibrosisLaboratory studyOther animals
- Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in MiceLaboratory studyOther animalsWith gabapentin
- A new co-micronized composite containing palmitoylethanolamide and polydatin shows superior oral efficacy compared to their association in a rat paw model of carrageenan-induced inflammationLaboratory studyOther animalsWith polydatin
- Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of acute and chronic inflammationLaboratory studyOther animalsWith adelmidrol (a PEA analogue, tested alone)
- Ultramicronized palmitoylethanolamide reduces viscerovisceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis: role of mast cellsLaboratory studyOther animals
- Safety of micronized palmitoylethanolamide (microPEA): lack of toxicity and genotoxic potentialLaboratory studyHumansOther animals
- N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanismLaboratory studyOther animals
- The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channelsLaboratory studyHumansDogsOther animals
- Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitisLaboratory studyDogsOther animals
- Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitisLaboratory studyOther animals
- Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptorsLaboratory studyOther animals
- Co-ultramicronized Palmitoylethanolamide/Luteolin Promotes the Maturation of Oligodendrocyte Precursor CellsLaboratory studyOther animalsWith luteolin
- Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agentLaboratory studyOther animals
- Enhancement of Antihyperalgesia by the Coadministration of N-palmitoylethanolamide and Acetaminophen in Diabetic RatsLaboratory studyOther animalsWith paracetamol (acetaminophen)
- Synergistic antinociceptive interaction between palmitoylethanolamide and tramadol in the mouse formalin testLaboratory studyOther animalsWith tramadol
- Delay of morphine tolerance by palmitoylethanolamideLaboratory studyOther animals
- Palmitoylethanolamide relieves pain and preserves pancreatic islet cells in a murine model of diabetesLaboratory studyOther animals
- Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic miceLaboratory studyOther animals
- Effects of palmitoylethanolamide and silymarin combination treatment in an animal model of kidney ischemia and reperfusionLaboratory studyOther animalsWith silymarin
- The anti-inflammatory effects of palmitoylethanolamide (PEA) on endotoxin-induced uveitis in ratsLaboratory studyOther animals
- Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminalsLaboratory studyOther animals
- Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin systemLaboratory studyOther animals
- Palmitoylethanolamide treatment reduces retinal inflammation in streptozotocin-induced diabetic ratsLaboratory studyOther animals
- Protective effect of palmitoylethanolamide in a rat model of cystitisLaboratory studyOther animals
- Interaction between the protective effects of cannabidiol and palmitoylethanolamide in experimental model of multiple sclerosis in C57BL/6 miceLaboratory studyOther animalsWith cannabidiol
- Differential Effects of Palmitoylethanolamide against Amyloid-β Induced Toxicity in Cortical Neuronal and Astrocytic Primary Cultures from Wild-Type and 3xTg-AD MiceLaboratory studyOther animals
- Improvement of Topical Palmitoylethanolamide Anti-Inflammatory Activity by Pegylated ProdrugsLaboratory studyOther animalsTopicalWith polyethylene glycol (PEG) prodrugs of PEA, tested alone as modified forms of PEA
- Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in RatsLaboratory studyOther animalsWith L-Val-PEA and D-Val-PEA (amino-acid ester prodrugs of PEA, tested alone)
- Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitisLaboratory studyDogs
- Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory painLaboratory studyOther animals
- Quantification of anandamide, oleoylethanolamide and palmitoylethanolamide in rodent brain tissue using high performance liquid chromatography-electrospray mass spectroscopyLaboratory studyOther animals
- Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogsLaboratory studyDogs
- Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in ratsLaboratory studyOther animals
- Administration of URB597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in ratsLaboratory studyOther animals
- Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNF-alpha release from canine skin mast cellsLaboratory studyDogs
- Effect of PEA on LPS inflammatory action in human adipocytesLaboratory studyHumans
- Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the ratLaboratory studyOther animals