Localization of cannabinoid receptors CB1, CB2, GPR55, and PPAR-alpha in the canine gastrointestinal tract

Galiazzo G, Giancola F, Stanzani A, Fracassi F, Bernardini C, Forni M, Pietra M, Chiocchetti R. Histochem Cell Biol. 2018;150(2):187-205.

Laboratory studyDogs

Design

Laboratory study

Subjects

Canine gastrointestinal tissue samples, ex vivo

Dose used in the study

No PEA given. Immunohistochemistry for four receptors

Duration

Not applicable

What was measured

Distribution of CB1, CB2, GPR55 and PPAR-alpha receptors in the dog gut wall.

What the authors reported

This laboratory study found:

• All four receptors were found in the dog gut.
• CB1 was in the lamina propria and epithelial cells.
• PPAR-alpha, the main proposed target of PEA, was on blood vessels, smooth muscle and glial cells of the myenteric plexus.
• CB2 was on mast cells and immune cells in the lamina propria.
• GPR55 was on lamina propria macrophages and smooth muscle cells.

Limits of this study

An anatomical mapping study. It shows the receptors exist in dog gut; it does not show that PEA acts on them there or that giving PEA changes anything. Listed because the mechanism pages rely on such maps.

Source

PubMed 29882158 · doi:10.1007/s00418-018-1684-7

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.