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Combination products

Many commercial products pair palmitoylethanolamide with another active compound. This page lists the published studies of those combinations, grouped by the partner compound.

A study of a combination tests the combination. Its result cannot be assigned to palmitoylethanolamide alone, or to the partner alone, unless the study included separate groups for each. Few do.

168 studies listed.

With 2-arachidonoyl glycerol

With 2-arachidonoylglycerol (2-AG

With a patented fatty acid mixture (OnLife)

With acetyl-L-carnitine

With acetyl-L-carnitine 500 mg (fixed combination Kalanit

With acetylethanolamine

With Acmella oleracea extract

With adelmidrol (a PEA analogue

With adelmidrol (a PEA analogue) with high molecular weight hyaluronic acid

With adelmidrol (a PEA analogue) with hyaluronic acid

With adelmidrol (a PEA analogue) with sodium hyaluronate (Colomast)

With alpha-lipoic acid

With alpha-lipoic acid (all treated patients received it; PEA was added in some)

With AM11095 (a brain-permeable NAAA inhibitor that raises the body's own palmitoylethanolamide) given with morphine; PEA itself was not given

With AM6545 (a peripheral CB1 receptor blocker

With amphotericin B (in one arm; palmitoylethanolamide also tested alone)

With ARN15381 (a FAAH inhibitor

With ARN19702

With ASP3652 (a FAAH inhibitor that raises endogenous PEA

With ASP8477 (a FAAH inhibitor that raises brain PEA

With astaxanthin

With atractylodin (a NAAA inhibitor that raises cellular PEA

With baicalein

With baicalin

With beta-caryophyllene

With bovine colostrum

With cannabidiol

With cannabidiol (tested alone; PEA was a measured lipid)

With Cucumis sativus extract (branded Ostizeel)

With D-mannose

With delta-9-tetrahydrocannabinol (THC)

With docosahexaenoic acid (DHA)

With Douchi (fermented soybean) extract used as Hataedock; genistein

With Epilobium

With Equisetum arvense (horsetail)

With Equisetum arvense L. (horsetail) extract

With F96 (a NAAA inhibitor that raises the body's own palmitoylethanolamide); PEA itself was not given

With fatty acid amides FAA1

With fucoxanthinol (a seaweed carotenoid that inhibits NAAA

With gabapentin

With geniposide (tested alone; PEA was a measured metabolite)

With GLUPEA (a glucuronic acid-PEA conjugate prodrug

With hemp oil extract

With hempseed oil

With Hericium erinaceus

With hydroxytyrosol (olive extract)

With INND-2201 (a co-drug combining pregabalin

With interferon beta (co-exposure); oleoylethanolamide tested in parallel

With JNJ-42165279 (a FAAH inhibitor that raises endogenous PEA

With Kluyveromyces marxianus B0399

With L-Val-PEA

With lipoic acid

With luteolin

With luteolin (co-ultramicronised palmitoylethanolamide

With luteolin (co-ultramicronised PEA plus luteolin

With luteolin (co-ultramicronised PEA-LUT)

With luteolin (co-ultramicronised PEA/luteolin

With luteolin (co-ultramicronised with palmitoylethanolamide

With luteolin (in the included trial)

With luteolin (in the single case study cited)

With luteolin (palmitoylethanolamide

With luteolin (PEA-LUT)

With luteolin (ultramicronised palmitoylethanolamide with luteolin

  • Infectious disease for the rhinologist
    Lu Hui Png et al. · Current Opinion in Otolaryngology & Head and Neck Surgery · 2024
    ReviewHumansWith luteolin (ultramicronised palmitoylethanolamide with luteolin, as discussed in the review)

With luteolin; alpha-lipoic acid in two arms

With melatonin

With morphine

With N-palmitoyl-D-glucosamine (a related ALIAmide

With N-palmitoylethanolamide-oxazoline (PEA-OXA

With NAAA gene deletion (CRISPR-Cas9) or the NAAA inhibitor F96

With NAAA gene deletion or NAAA inhibitors

With oleoylethanolamide (OEA

With paracetamol

With paracetamol (acetaminophen)

With PEA-OXA (2-pentadecyl-2-oxazoline

With PEA-OXA (a PEA analogue

With phycocyanin

With polydatin

With polydatin (comicronised with ultramicronised PEA)

With polydatin (palmitoylethanolamide-polydatin was one of the therapies reviewed)

With polyethylene glycol (PEG) prodrugs of PEA

With pregabalin

With probiotics (Bifidobacterium animalis BB12

With quercetin

With RePEA (a PEA analogue

With Reviewed studies included PEA-combination medicines (partners not named in the abstract) alongside cannabis products

With RN1734 (a TRPV4 antagonist)

With rutin

With silymarin

With Small-molecule NAAA inhibitors

With sodium cromoglycate (proposed partner)

With spermidine

With superoxide dismutase

With tapentadol

With topiramate

With tramadol

With transpolydatin

With URB597

With URB866 (a NAAA inhibitor that raises the body's own palmitoylethanolamide)

With URB937 (a FAAH inhibitor that raises endogenous PEA

With URB937 (a peripheral FAAH inhibitor)

With Zingiber officinale