The ventral pallidum as a critical region for fatty acid amide hydrolase inhibition of nausea-induced conditioned gaping in male Sprague-Dawley rats
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Male Sprague-Dawley rats; numbers not stated in the abstract
- Dose used in the study
- No palmitoylethanolamide was given; the FAAH inhibitor PF-3845 and the PPAR-alpha agonist GW7647 injected into the ventral pallidum
- Duration
- Not stated in the abstract
- What was measured
- Lithium chloride-induced conditioned gaping, a rat model of acute nausea; the roles of CB1 and PPAR-alpha receptors
What the authors reported
PF-3845 into the ventral pallidum reduced conditioned gaping in a dose-dependent way through PPAR-alpha, not CB1. GW7647 into the same region also reduced gaping. The authors suggest the anti-nausea action of FAAH inhibition occurs in the ventral pallidum via PPAR-alpha, the receptor palmitoylethanolamide acts on.
Limits of this study
A rat study; PEA itself was not given and it cannot show effect in people. Doses and animal numbers are not in the abstract. Funding and conflicts not stated in the abstract.
Source
PubMed 31145905 · doi:10.1016/j.neuropharm.2019.05.031
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.