Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway

Serena Boccella, Claudia Cristiano, Rosaria Romano, Monica Iannotta, Carmela Belardo, Antonio Farina, Francesca Guida, Fabiana Piscitelli, Enza Palazzo, Mariacristina Mazzitelli, Roberta Imperatore, Lea Tunisi, Vito de Novellis, Luigia Cristino, Vincenzo Di Marzo, Antonio Calignano, Sabatino Maione, Livio Luongo. Neurobiol Dis. 2019 Jan;121:106-119.

Laboratory studyOther animals

Design

Laboratory study

Subjects

Mice with spared nerve injury (SNI) of the sciatic nerve, and PPARalpha-null mice

Dose used in the study

Not stated in the abstract

Duration

Chronic treatment starting once neuropathic pain was fully developed; exact duration not stated

What was measured

Mechanical and thermal pain thresholds, spatial memory, long-term potentiation (LTP) at the entorhinal cortex-dentate gyrus pathway, and glutamatergic synapse markers

What the authors reported

Nerve injury reduced pain thresholds, spatial memory and LTP, altered dentate gyrus synapse structure and glutamate receptor expression, and raised glutamate and 2-AG levels. Chronic PEA reversed the pain, memory and LTP deficits and restored synaptic changes in wild-type mice, but not in PPARalpha-null mice.

Limits of this study

A mouse model of nerve-injury pain; it cannot show effect in people. Funding and conflicts not stated in the abstract.

Source

PubMed 30266286 · doi:10.1016/j.nbd.2018.09.023

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.