Oleoylethanolamide and Palmitoylethanolamide Enhance IFNβ-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells
Laboratory studyHumansWith interferon beta (co-exposure); oleoylethanolamide tested in parallel
This study tested palmitoylethanolamide together with interferon beta (co-exposure); oleoylethanolamide tested in parallel. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Human SH-SY5Y neuroblastoma cell line
- Dose used in the study
- Not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Cell viability, proliferation, apoptosis markers (cleaved caspase 3, PARP, survivin, IKB-alpha), JAK-STAT and PKR signalling, p38 MAP kinase and PD-L1 expression.
What the authors reported
The study found:
- Adding either OEA or PEA to interferon beta increased apoptotic cell death, with more cleaved caspase 3 and PARP and less survivin and IKB-alpha.
- Neither lipid changed interferon signalling through JAK-STAT or PKR.
- Both raised p38 phosphorylation and PD-L1 expression.
- Blocking or silencing PPAR-alpha lowered PD-L1 and cleaved PARP.
Limits of this study
A cancer cell line study; it cannot show effect in people. No doses or exposure times are given in the abstract. The authors declare no conflict of interest.
Source
PubMed 38611871 · doi:10.3390/molecules29071592
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.