Effects of palmitoylethanolamide and silymarin combination treatment in an animal model of kidney ischemia and reperfusion
Laboratory studyOther animalsWith silymarin
This study tested palmitoylethanolamide together with silymarin. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Mice with bilateral kidney artery occlusion (30 minutes) followed by 6 hours of reperfusion
- Dose used in the study
- Silymarin (100, 30 or 10 mg/kg) or PEA (1 mg/kg) or PEA (1 mg/kg) plus silymarin (10 mg/kg), given into the abdomen 15 minutes before clamp release
- Duration
- 30 minutes of ischaemia plus 6 hours of reperfusion
- What was measured
- Kidney dysfunction markers, tissue damage, neutrophil infiltration (myeloperoxidase), oxidative stress (malondialdehyde), NF-kB pathway and apoptosis markers.
What the authors reported
Silymarin alone reduced kidney dysfunction, tissue damage, neutrophil infiltration and oxidative stress in a dose-dependent way. The PEA plus silymarin combination, even at lower individual doses, produced a significantly larger effect than either alone, with greater inhibition of NF-kB and apoptosis pathways.
Limits of this study
A mouse model of surgically induced kidney ischaemia and reperfusion; it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 25981305 · doi:10.1016/j.ejphar.2015.05.010
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.