Palmitoylethanolamide treatment reduces retinal inflammation in streptozotocin-induced diabetic rats
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Streptozotocin-induced diabetic rats, eyes examined 15 and 60 days after diabetes induction
- Dose used in the study
- PEA 10 mg/kg by mouth daily, starting 3 days after streptozotocin injection
- Duration
- Up to 60 days
- What was measured
- Retinal levels of VEGF, ICAM-1, nitrotyrosine and tight junction proteins by immunohistochemistry, as markers of blood-retinal barrier breakdown, in rats given 10 mg/kg PEA orally daily starting 3 days after diabetes induction, with eyes examined at 15 and 60 days.
What the authors reported
VEGF, ICAM-1, nitrotyrosine and tight junctions were present in the retina of the diabetic rats. The extent of injury was significantly reduced after PEA treatment, and the authors state that PEA attenuated inflammation while preserving the blood-retinal barrier, based on immunohistochemical analysis.
Limits of this study
A rat model of streptozotocin-induced diabetes; it cannot show effect in people with diabetic retinopathy. Funding and conflicts not stated in the abstract.
Source
PubMed 26607470 · doi:10.1016/j.ejphar.2015.11.035
Entry checked against the abstract on PubMed on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.