NAAA inhibitor F96 attenuates BBB disruption and secondary injury after traumatic brain injury (TBI)
Laboratory studyOther animalsWith F96 (a NAAA inhibitor that raises the body's own palmitoylethanolamide); PEA itself was not given
This study tested palmitoylethanolamide together with F96 (a NAAA inhibitor that raises the body's own palmitoylethanolamide); PEA itself was not given. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Animals with traumatic brain injury; species and numbers not stated in the abstract
- Dose used in the study
- Not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- PEA levels in injured cortex; neutrophil infiltration and NAAA; blood-brain barrier disruption; secondary injury and long-term function.
What the authors reported
The study found:
- Brain injury raised PEA in the injured cortex, which the authors say protects the blood-brain barrier.
- Infiltrating neutrophils carried NAAA, which degraded PEA and weakened that protection.
- Inactivating NAAA raised PEA at the injury site, prevented early barrier damage, reduced secondary injury and improved long-term function.
Limits of this study
An animal model; it cannot show effect in people. No palmitoylethanolamide was given; the inhibitor raised the body's own PEA. Species and numbers are not in the abstract. Funding and conflicts not stated in the abstract.
Source
PubMed 34655598 · doi:10.1016/j.ejphar.2021.174561
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.