Palmitoylethanolamide relieves pain and preserves pancreatic islet cells in a murine model of diabetes
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Streptozotocin-induced diabetic mice (a model of type 1 diabetes)
- Dose used in the study
- PEA, given into the abdomen; exact dose not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Mechanical allodynia, nerve growth factor levels, insulin levels, and pancreatic Langerhans islet structure and insulitis
What the authors reported
PEA reduced mechanical allodynia, countered a deficit in nerve growth factor, raised insulin levels, and preserved Langerhans islet structure while reducing insulitis in diabetic mice.
Limits of this study
A mouse model of streptozotocin-induced type 1 diabetes; it cannot show effect in people with diabetes. Dose is not stated in the abstract. Funding and conflicts not stated in the abstract.
Source
PubMed 25921749 · doi:10.2174/1871527314666150429111537
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.