Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice

Emma Zambrana-Infantes, Cristina Rosell Del Valle, David Ladrón de Guevara-Miranda, Pablo Galeano, Estela Castilla-Ortega, Fernando Rodríguez De Fonseca, Eduardo Blanco, Luis Javier Santín. Pharmacol Biochem Behav. 2018 Mar;166:1-12.

Laboratory studyOther animals

Design

Laboratory study

Subjects

Male C57BL/6J mice given cocaine to induce behavioural sensitization and conditioned place preference (CPP)

Dose used in the study

PEA 1 or 10 mg/kg, intraperitoneal, given repeatedly or acutely

Duration

Not stated precisely in the abstract

What was measured

Acquisition and expression of cocaine-induced behavioural sensitization (BS) and conditioned place preference (CPP)

What the authors reported

Repeated PEA at both doses blocked acquisition of cocaine-induced behavioural sensitization. Acute PEA at both doses stopped expression of behavioural sensitization, and the higher dose also stopped expression of conditioned place preference.

Limits of this study

A mouse model of drug addiction; it cannot show effect in people. Funding and conflicts not stated in the abstract.

Source

PubMed 29337083 · doi:10.1016/j.pbb.2018.01.002

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.