Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Rats with knee osteoarthritis induced by intra-articular monosodium iodoacetate; numbers not stated in the abstract
- Dose used in the study
- Palmitoylethanolamide, WIN-55,212 and HU210 at several doses; route not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Paw withdrawal threshold (von Frey), weight-bearing difference and open-field locomotion; reversal by the CB1 antagonist SR141716A and the PPAR-alpha antagonist GW6471.
What the authors reported
All three compounds restored paw withdrawal threshold and weight-bearing in a dose-dependent way and restored locomotor activity. The CB1 antagonist reversed the withdrawal-threshold effect of all three but reversed weight-bearing only for HU210. The PPAR-alpha antagonist reversed the effects of PEA but not the synthetic cannabinoids.
Limits of this study
A rat model of osteoarthritis; it cannot show effect in people or animals treated in practice. Doses, route and numbers are not in the abstract. Funding and conflicts not stated in the abstract.
Source
PubMed 30945071 · doi:10.1007/s10787-019-00584-7
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.