In Vitro and In Vivo Safety of Hyaluronic Acid-Decorated Microparticles for Intravitreal Injection of Palmitoylethanolamide, Citicoline, or Glial-Cell-Derived Neurotrophic Factor
Laboratory studyHumansOther animals
- Design
- Laboratory study
- Subjects
- Human ARPE-19 retinal pigment epithelial cells and an unspecified in vivo model
- Dose used in the study
- PLGA microparticles decorated with hyaluronic acid and loaded with palmitoylethanolamide, citicoline or GDNF, for intravitreal injection; amounts not stated
- Duration
- Not stated in the abstract
- What was measured
- Microparticle characteristics, cell viability in vitro, and in vivo safety of empty and loaded particles
What the authors reported
This safety study found:
- Microparticles had a satisfactory safety profile on ARPE-19 cells.
- Free GDNF reduced cell viability while sustained-release GDNF did not.
- In vivo results confirmed the safety of both empty and loaded microparticles.
- No efficacy was tested.
Limits of this study
A safety and formulation study in cells and an animal model; it cannot show effect in people. The abstract does not name the animal species or give doses. Funding and conflicts not stated in the abstract.
Source
PubMed 37531486 · doi:10.1021/acs.biomac.3c00276
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.