Differential Effects of Palmitoylethanolamide against Amyloid-β Induced Toxicity in Cortical Neuronal and Astrocytic Primary Cultures from Wild-Type and 3xTg-AD Mice
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Primary cortical neuron and astrocyte cultures from wild-type mice and from 3xTg-AD (Alzheimer's model) mice
- Dose used in the study
- PEA, 0.1 micromolar, given before exposure to amyloid-beta 42 (0.5 micromolar) for 24 hours
- Duration
- 24 hours of amyloid-beta exposure
- What was measured
- Cell viability and glutamate levels in cultured cortical neurons and astrocytes from wild-type and 3xTg-AD mice, with and without PEA pre-treatment.
What the authors reported
Amyloid-beta reduced cell viability and altered glutamate levels in cultured neurons and astrocytes from wild-type mice, but not in cells from 3xTg-AD mice. PEA countered these amyloid-beta effects in wild-type-derived cells, but PEA alone did not change cell viability or glutamate levels in cultured cells from either mouse strain.
Limits of this study
A cell-culture study using mouse-derived neurons and astrocytes; it cannot show effect in people with Alzheimer's disease. Funding and conflicts not stated in the abstract.
Source
PubMed 25765918 · doi:10.3233/JAD-143039
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.