In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and Palmitoylethanolamide
Laboratory studyOther animalsWith Hericium erinaceus, bilberry extract and Centella asiatica
This study tested palmitoylethanolamide together with Hericium erinaceus, bilberry extract and Centella asiatica. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- 3D intestinal epithelial cell model; co-culture of neuronal and astrocytic cells, under oxidative stress
- Dose used in the study
- Not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Intestinal barrier integrity (TEER, tight junctions); inflammatory markers (NF-kappa-B, TNF-alpha, IL-1beta, IL-6), reactive oxygen species and nitric oxide; mitochondrial activity and antioxidant response; BDNF and NGF; APP, phosphorylated tau, Sirtuin 1 and Nrf2.
What the authors reported
The combination preserved intestinal barrier integrity. Under oxidative stress, it cut inflammatory markers by about 1.5-fold, reactive oxygen species by about 2-fold and nitric oxide by about 1.2-fold versus H2O2 controls, raised BDNF and NGF (about 2.3- and 1.9-fold), lowered APP by about 98% and phosphorylated tau by about 1.6-fold, and raised Sirtuin 1 and Nrf2 (about 3.6- and 3-fold).
Limits of this study
An in vitro cell and gut-brain axis model study; it cannot show effect in people. One author was employed by, and another co-founded, the company noiVita S.r.l.s, which the abstract states had no role in interpreting the data.
Source
PubMed 40807615 · doi:10.3390/foods14152678
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.