Effect of PEA on LPS inflammatory action in human adipocytes

Hoareau L, Ravanan P, Gonthier MP, Delarue P, Goncalves J, Cesari M, Festy F, Roche R. Cytokine. 2006;34(5-6):291-296.

Laboratory studyHumans

Design

Laboratory study

Subjects

Human mature fat cells in culture

Dose used in the study

PEA added to culture with bacterial lipopolysaccharide

Duration

Cell culture

What was measured

IL-6 secretion via NF-kappa-B, and leptin release.

What the authors reported

PEA did not block the lipopolysaccharide-driven rise in IL-6, but it did strengthen the lipopolysaccharide-driven fall in leptin release. This suggests PEA is not anti-inflammatory at the fat-cell level for this pathway, the authors conclude.

Limits of this study

Cell study. Listed because it is one of the few papers reporting no anti-inflammatory effect in a human cell type, which balances the many positive mechanism papers. Independent French group.

Source

PubMed 16884908 · doi:10.1016/j.cyto.2006.06.005

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.