Enhancement of Antihyperalgesia by the Coadministration of N-palmitoylethanolamide and Acetaminophen in Diabetic Rats
Laboratory studyOther animalsWith paracetamol (acetaminophen)
This study tested palmitoylethanolamide together with paracetamol (acetaminophen). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Streptozotocin-induced diabetic rats tested in the formalin paw test
- Dose used in the study
- PEA (1-100 micrograms per paw) and acetaminophen (3-300 micrograms per paw), injected under the skin of the paw, alone and combined in a fixed 1:1 ratio
- Duration
- Not stated in the abstract
- What was measured
- Pain response in the formalin test after PEA and acetaminophen, alone and combined, analysed by isobolographic method for synergy
What the authors reported
PEA and acetaminophen each reduced pain in a dose-dependent way, with PEA more potent (EC50 7.19 ± 0.7 micrograms per paw) than acetaminophen (EC50 57.9 ± 1.9 micrograms per paw). Combined, they produced a synergistic effect: the effective combined dose (23.64 ± 1.9 micrograms per paw) was lower than the dose calculated from adding the two drugs' individual effects (32.56 micrograms per paw).
Limits of this study
A rat model of diabetes-related pain; it cannot show effect in people with diabetic neuropathy. Funding and conflicts not stated in the abstract.
Source
PubMed 26218800 · doi:10.1002/ddr.21259
Entry checked against the abstract on PubMed on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.