Impaired brain endocannabinoid tone in the activity-based model of anorexia nervosa
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Female rats in the activity-based anorexia model; numbers not stated in the abstract
- Dose used in the study
- No palmitoylethanolamide was given; brain levels were measured
- Duration
- Measured at the end of induction and after recovery
- What was measured
- Anandamide, 2-AG, oleoylethanolamide and palmitoylethanolamide levels and CB1 receptor density in prefrontal cortex, nucleus accumbens, caudate putamen, amygdala, hippocampus and hypothalamus.
What the authors reported
The study found:
- At the end of induction 2-AG was reduced in most regions.
- Anandamide was unchanged, while oleoylethanolamide and palmitoylethanolamide were reduced only in hippocampus and hypothalamus.
- CB1 density fell in the dentate gyrus and lateral hypothalamus.
- After recovery 2-AG and CB1 partly normalised but anandamide became markedly reduced in all regions.
Limits of this study
A rat model measuring endogenous levels; no PEA was given and it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 31456239 · doi:10.1002/eat.23157
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.