Synergistic modulation of nociceptive and inflammatory pain by palmitoylethanolamide and Cucumis sativus extract in a monosodium-iodoacetate induced osteoarthritic rat model
Laboratory studyOther animalsWith Cucumis sativus extract (branded Ostizeel)
This study tested palmitoylethanolamide together with Cucumis sativus extract (branded Ostizeel). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- 42 female Wistar rats with monosodium iodoacetate-induced osteoarthritis, in seven groups
- Dose used in the study
- PEA, Cucumis sativus extract, an NSAID standard, or combinations, given orally for 28 days
- Duration
- 28 days
- What was measured
- Nociceptive behaviour (movement-evoked pain, Randall-Selitto, von Frey, weight-bearing), serum interleukin-1beta and MMP-13, and drug interaction using Bliss Independence and combination index analysis
What the authors reported
The PEA plus Cucumis sativus combination improved pain thresholds and limb function more than either alone (p<0.0001) and cut serum IL-1beta and MMP-13 by about 50%. Bliss Independence analysis showed positive synergy scores across behavioural and biochemical measures.
Limits of this study
A rat model of chemically induced osteoarthritis; it cannot show effect in people or animals with naturally occurring osteoarthritis. The authors declare no competing interests; the study used a proprietary combination (Ostizeel) from a commercial research organisation.
Source
PubMed 41945007 · doi:10.1007/s10787-026-02197-3
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.