Sustained Palmitoylethanolamide Infusion Restores Incentive Motivation and Synaptic Plasticity in the Tg2576 Mouse Model of Alzheimer's Disease
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Tg2576 transgenic mice (Alzheimer's model) and wild-type mice
- Dose used in the study
- Sustained-release PEA pellets, implanted, continuous infusion
- Duration
- 6 months
- What was measured
- Motivational behaviour by conditioned place preference; dendritic spine morphology in entorhinal cortex, dentate gyrus and prefrontal cortex; PPAR-alpha and BDNF expression, after 6 months of sustained-release PEA pellet infusion.
What the authors reported
PEA rescued conditioned place preference performance in Tg2576 mice, increased basal dendritic spines in wild-type mice in the entorhinal cortex, increased basal and apical dendritic expression in the entorhinal cortex and dentate gyrus of Tg2576 mice, and increased PPAR-alpha and BDNF expression in the prefrontal cortex. The BDNF increase also occurred in the absence of baseline deficits.
Limits of this study
A mouse model study using sustained PEA infusion pellets, not oral dosing; it cannot show effect in people or in animals treated by mouth. The authors declare no conflicts of interest.
Source
PubMed 42041537 · doi:10.3390/cells15080669
Entry checked against the abstract on PubMed on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.