Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Mice fed an oleic acid diet or a low oleic acid diet; numbers not stated in the abstract
- Dose used in the study
- No palmitoylethanolamide was given; diets contained 38.4 or 3.1 mg oleic acid per gram, with oleic acid or OEA treatment in some groups
- Duration
- Two weeks
- What was measured
- Jejunal OEA, LEA and PEA levels; food intake and body weight gain; response to switching diets and to oleic acid or OEA treatment.
What the authors reported
This laboratory study found:
- Mice on the low oleic acid diet had lower jejunal OEA but unchanged LEA and PEA, ate more and gained more weight.
- The rise in intake appeared at once after the switch and reversed on switching back.
- Oleic acid or OEA treatment reduced the effect.
Limits of this study
A mouse study; it cannot show effect in people or animals treated in practice. PEA was measured, not given, and did not change. The authors declare no commercial or financial conflicts.
Source
PubMed 36733808 · doi:10.3389/fendo.2022.1056116
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.