Palmitoylethanolamide: the research, in one place
Palmitoylethanolamide (PEA) is a fatty acid amide that the body makes. Researchers have studied it since the 1950s, in people and in animals, by mouth and on the skin. This site lists that research, with each study's design, size, dose and limits. It does not give advice and does not sell anything.
601 studies from 2001 to 2026, including 69 randomised controlled trials. Each entry was checked against its source.
By species
- Humans 349 studies
- Dogs 20 studies
- Cats 11 studies
- Horses 2 studies
- Other animals and laboratory 332 studies
By route and product
Human research by topic
- Chronic and neuropathic pain 112 studies
- Joints 12 studies
- Pelvic pain and endometriosis 19 studies
- Migraine and headache 10 studies
- Sleep 8 studies
- Gut 24 studies
- Mood and brain 91 studies
- Respiratory and immune 24 studies
- Sense of smell 14 studies
- Eyes 11 studies
- Metabolic health 24 studies
- Exercise recovery 10 studies
- Safety in human trials 19 studies
Background
Recently added
- N-Palmitoylethanolamide enhances antinociceptive effect of tramadol in neuropathic rats
PEA alone was about five times more potent than tramadol against hyperalgesia and about eight times more potent against allodynia.
Laboratory studyOther animalsWith tramadol - Review of Alzheimer's disease drugs and their relationship with neuron-glia interaction
The abstract gives no specific findings on palmitoylethanolamide.
ReviewHumansOther animals - Bioactive lipids in inflammatory bowel diseases - From pathophysiological alterations to therapeutic opportunities
The abstract does not single out palmitoylethanolamide findings or give numbers.
ReviewHumansOther animals - Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis
PEA and related lipids were higher in atopic skin than in healthy skin, PEA most of all.
Laboratory studyDogs
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