Impaired Duodenal Palmitoylethanolamide Release Underlies Acid-Induced Mast Cell Activation in Functional Dyspepsia
Laboratory studyHumansOther animals
- Design
- Laboratory study
- Subjects
- Duodenal biopsies from patients with functional dyspepsia and from controls, plus PPAR-alpha knockout mice
- Dose used in the study
- Biopsies cultured at pH 3.0 or 7.4, with PEA added at several concentrations, alone or with PPAR-alpha or PPAR-gamma blockers
- Duration
- Tissue culture
- What was measured
- Mast cell number and mediator release; TRPV1 and TRPV4 expression; endogenous PEA release
What the authors reported
This laboratory study found:\n- Acid raised mast cell density and mediator release in all biopsies, more so in dyspepsia; this response was mediated by submucosal nerve fibres, since blocking neuronal signalling with tetrodotoxin reduced the mast cell infiltration.\n- The tissue's own PEA release in response to acid was impaired in dyspepsia.\n- Added PEA reduced the mast cell activation and TRPV up-regulation.
Limits of this study
A tissue culture study of mechanism. No patient was given PEA. The findings suggest a target, not a treatment effect.
Source
PubMed 33065341 · doi:10.1016/j.jcmgh.2020.10.001
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.