Pyridostigmine bromide exposure creates chronic, underlying neuroimmune disruption in the gastrointestinal tract and brain that alters responses to palmitoylethanolamide in a mouse model of Gulf War Illness
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Mice exposed to pyridostigmine bromide (PB), a Gulf War Illness model, then given PEA
- Dose used in the study
- PEA administered after PB exposure; dose not stated in the abstract
- Duration
- Effects tracked up to 5 months after exposure
- What was measured
- Neuromuscular transmission; calcium imaging of TRPV1, endocannabinoid and PPAR-alpha signalling; glial reactivity; enteric neurochemical coding and survival; pro-inflammatory cytokines and chemokines in brain and colon; sex differences.
What the authors reported
PB alone caused little change in neuromuscular transmission, but altered how PEA affected the gut and brain. This involved shifts in TRPV1, endocannabinoid and PPAR-alpha signalling, glial reactivity, and enteric neurochemical changes. PB and PEA together caused pro-inflammatory shifts that lasted up to 5 months, with marked sex differences.
Limits of this study
A mouse-model study; it cannot show effect in people. The authors declare no conflicts of interest.
Source
PubMed 32758565 · doi:10.1016/j.neuropharm.2020.108264
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.