Co-Ultra PEALut Enhances Endogenous Repair Response Following Moderate Traumatic Brain Injury
Laboratory studyHumansOther animalsWith luteolin (co-ultramicronised PEA plus luteolin, Glialia)
This study tested palmitoylethanolamide together with luteolin (co-ultramicronised PEA plus luteolin, Glialia). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Mice with traumatic brain injury, assessed at 72 hours and 7 days; plus a preliminary clinical trial in patients with moderate traumatic brain injury (number not stated)
- Dose used in the study
- Not stated in the abstract
- Duration
- Up to 7 days after injury in mice; not stated for the patients
- What was measured
- Neurogenesis and neuronal reconstitution, neurotrophic factors and memory behaviour in mice; working memory recovery in patients.
What the authors reported
The study found:
- Co-ultramicronised PEA plus luteolin helped restore basal levels of new and mature neurons after injury in mice, raised neurotrophic factors, and improved memory recall in behavioural tests.
- Preliminary clinical findings suggested Glialia treatment aided recovery of working memory.
- No numbers are given in the abstract.
Limits of this study
Mainly a mouse model; the clinical part is described as preliminary with no size, design or numbers stated. The record says "no other authors have conflict of interests", which implies a conflict for at least one author that the abstract does not show.
Source
PubMed 34445417 · doi:10.3390/ijms22168717
Entry checked against the abstract on PubMed on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.