Co-Ultra PEALut Enhances Endogenous Repair Response Following Moderate Traumatic Brain Injury
Laboratory studyHumansOther animalsWith luteolin (co-ultramicronised PEA plus luteolin, Glialia)
This study tested palmitoylethanolamide together with luteolin (co-ultramicronised PEA plus luteolin, Glialia). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Mice with traumatic brain injury, assessed at 72 hours and 7 days; plus a preliminary clinical trial in patients with moderate traumatic brain injury (number not stated)
- Dose used in the study
- Not stated in the abstract
- Duration
- Up to 7 days after injury in mice; not stated for the patients
- What was measured
- Neurogenesis and neuronal reconstitution, neurotrophic factors and memory behaviour in mice; working memory recovery in patients.
What the authors reported
The study found:
- Co-ultramicronised PEA plus luteolin helped restore basal levels of new and mature neurons after injury in mice, raised neurotrophic factors, and improved memory recall in behavioural tests.
- Preliminary clinical findings suggested Glialia treatment aided recovery of working memory.
- No numbers are given in the abstract.
Limits of this study
Mainly a mouse model; the clinical part is described as preliminary with no size, design or numbers stated. Glialia is an Epitech product. The record says "no other authors have conflict of interests", which implies a conflict for at least one author that the abstract does not show.
Source
PubMed 34445417 · doi:10.3390/ijms22168717
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.