Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNF-alpha release from canine skin mast cells
Laboratory studyDogs
- Design
- Laboratory study
- Subjects
- Mast cells freshly isolated from canine skin biopsies, sensitised with IgE-rich serum and challenged with anti-canine IgE
- Dose used in the study
- PEA from 10 nanomolar to 10 micromolar in vitro
- Duration
- In vitro challenge
- What was measured
- Histamine, prostaglandin D2 and TNF-alpha release
What the authors reported
PEA inhibited release of all three mediators. Peak histamine inhibition was 54 percent at 3 micromolar; PGD2 inhibition 26 percent at 10 micromolar; TNF-alpha inhibition 29 percent at 10 micromolar.
Limits of this study
In vitro cell study. Two authors are from Innovet, which makes veterinary PEA products. Partial inhibition, not abolition, of mediator release.
Source
PubMed 19625090 · doi:10.1016/j.vetimm.2009.06.011
Entry checked against the abstract, supplied by Devlin on 2026-09-21. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.