Chronic Psychosocial Stress Causes Increased Anxiety-Like Behavior and Alters Endocannabinoid Levels in the Brain of C57Bl/6J Mice
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Two-month-old male C57Bl/6J mice: 11 exposed to chronic social defeat stress and 12 controls
- Dose used in the study
- No palmitoylethanolamide was given; brain levels were measured
- Duration
- 3 weeks of stress
- What was measured
- Anxiety behaviour in light-dark box and hole board tests; body weight; 2-AG, anandamide, OEA and palmitoylethanolamide in hippocampus, cerebellum and cortex by LC-MS/MS.
What the authors reported
This lab study found:
- Stressed mice showed more anxiety behaviour and gained more weight.
- 2-AG was higher in cortex and cerebellum, anandamide lower in hippocampus, and OEA lower in hippocampus.
- The abstract reports no significant change in palmitoylethanolamide.
Limits of this study
A mouse stress study with 11 and 12 animals per group; it cannot show effect in people. PEA was measured, not given, and did not change. The authors declare no competing interests.
Source
PubMed 32322676 · doi:10.1089/can.2019.0041
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.