Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Rats with lipopolysaccharide-induced cystitis and normal controls; numbers not stated in the abstract
- Dose used in the study
- No palmitoylethanolamide was given; the FAAH inhibitor URB937 at several doses, route not stated
- Duration
- Not stated in the abstract
- What was measured
- Bladder reflex activity, pain responses and bladder tissue levels of anandamide and palmitoylethanolamide.
What the authors reported
URB937 did not change normal bladders. In inflamed bladders it had a U-shaped dose response: low doses reduced pain and normalised reflex activity via CB1, higher doses increased both via TRPV1. Cystitis raised anandamide and lowered palmitoylethanolamide. The effective dose normalised both, while high doses left them at inflamed levels. Benefit tracked the anandamide to PEA ratio, not anandamide alone, the authors conclude.
Limits of this study
A rat model of cystitis; PEA itself was not given and it cannot show effect in people. Doses, route and animal numbers are not in the abstract. Funding and conflicts not stated in the abstract.
Source
PubMed 31522241 · doi:10.1007/s00210-019-01729-9
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.