Partial Reversal of Striatal Damage by Palmitoylethanolamide Administration Following Perinatal Asphyxia
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Newborn rat pups subjected to a perinatal asphyxia model (Bjelke method), then followed for 30 days
- Dose used in the study
- PEA, 10 mg/kg, subcutaneous, given one hour after asphyxia
- Duration
- 30 days
- What was measured
- Striatal neuron markers (phosphorylated neurofilament pNF-H/M, MAP-2) and astrocyte marker GFAP, by western blot and immunohistochemistry.
What the authors reported
Perinatal asphyxia reduced pNF-H/M and MAP-2 reactive areas and protein expression, and reduced GFAP-positive cell numbers, without changing total GFAP protein. PEA treatment largely restored GFAP-positive cell numbers, improved the reduction in pNF-H/M and MAP-2 reactive areas, reversed the fall in MAP-2 and largely prevented the fall in pNF-H/M protein expression.
Limits of this study
A neonatal rat model of asphyxia; it cannot show effect in infants. Funding and conflicts not stated in the abstract.
Source
PubMed 31969800 · doi:10.3389/fnins.2019.01345
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.