Oleoylethanolamide and Palmitoylethanolamide Protect Cultured Cortical Neurons Against Hypoxia

Manuel Portavella, Nieves Rodriguez-Espinosa, Pablo Galeano, Eduardo Blanco, Juan I Romero, Mariana I Holubiec, Fernando Rodriguez de Fonseca, Emilio Fernández-Espejo. Cannabis Cannabinoid Res. 2018 Sep 19;3(1):171-178.

Laboratory studyOther animalsWith RN1734 (a TRPV4 antagonist), co-treated with PEA in some experiments; oleoylethanolamide (OEA) tested alongside PEA

This study tested palmitoylethanolamide together with RN1734 (a TRPV4 antagonist), co-treated with PEA in some experiments; oleoylethanolamide (OEA) tested alongside PEA. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.

Design

Laboratory study

Subjects

Cultured parietotemporal cortical neurons from newborn rats and mice

Dose used in the study

Not stated precisely in the abstract

Duration

Not stated in the abstract

What was measured

Neuroprotection of cortical neurons against a hypoxic episode, and the role of PPARalpha, TRPV1 and TRPV4 receptors

What the authors reported

OEA and PEA protected cultured cortical neurons from hypoxia. This protection did not depend on PPARalpha, TRPV1 or TRPV4, since PPARalpha-knockout mice and receptor ligands did not change it. Blocking TRPV4 was itself protective, and combining this blocker with OEA or PEA enhanced the protective effect.

Limits of this study

A cell-culture study; it cannot show effect in animals or people. Funding and conflicts not stated in the abstract.

Source

PubMed 30255158 · doi:10.1089/can.2018.0013

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.