Effects of fatty acid metabolites on nocturia
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Wild-type mice and Clock mutant mice (a model of nocturia); numbers not stated in the abstract
- Dose used in the study
- Palmitoylethanolamide, 9-HODE or 4-HDoHE administered to wild-type mice; dose and route not stated in the abstract
- Duration
- Serum sampled every 8 hours
- What was measured
- Circadian serum levels of PEA, 9-HODE and 4-HDoHE; voiding frequency and bladder capacity in metabolic cages after giving each lipid.
What the authors reported
This laboratory study found:
- Serum PEA and 9-HODE followed a daily rhythm in normal mice and were higher and lost their rhythm in Clock mutant mice.
- Giving PEA or 4-HDoHE increased voiding frequency, and PEA decreased bladder capacity.
- The authors say these changes resemble those in elderly people with nocturia.
Limits of this study
A mouse study; it cannot show effect in people. It reports that palmitoylethanolamide increased voiding and reduced bladder capacity, an unwanted effect in this model. Dose is not in the abstract. The authors declare no competing interests.
Source
PubMed 35197540 · doi:10.1038/s41598-022-07096-5
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.