Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer's disease by exerting anti-inflammatory and neuroprotective effects

Caterina Scuderi, Maria Rosanna Bronzuoli, Roberta Facchinetti, Lorenzo Pace, Luca Ferraro, Kevin Donald Broad, Gaetano Serviddio, Francesco Bellanti, Gianmauro Palombelli, Giulia Carpinelli, Rossella Canese, Silvana Gaetani, Luca Steardo Jr, Luca Steardo, Tommaso Cassano. Transl Psychiatry. 2018 Jan 31;8(1):32.

Laboratory studyOther animals

Design

Laboratory study

Subjects

Young (6-month) and adult (12-month) 3xTg-AD mice

Dose used in the study

Ultramicronised PEA (um-PEA), delivered subcutaneously

Duration

3 months

What was measured

Learning and memory, depressive and anhedonia-like behaviour, amyloid-beta formation, tau phosphorylation, neuronal survival, astrocyte function, glutamatergic transmission and neuroinflammation

What the authors reported

Um-PEA improved learning, memory and depressive/anhedonia-like behaviour, reduced amyloid-beta formation and tau phosphorylation, and supported neuronal survival in hippocampal CA1. It normalised astrocyte function and reduced neuroinflammation, with stronger effects in younger mice.

Limits of this study

A transgenic mouse model of Alzheimer's disease; it cannot show effect in people. Authors declare no competing interests; other funding links not stated in the abstract.

Source

PubMed 29382825 · doi:10.1038/s41398-017-0076-4

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.