Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Male laboratory rats, 12 to 18 per group, with an inflammatory granuloma induced by a carrageenan-soaked sponge
- Dose used in the study
- 200, 400 or 800 micrograms per mL injected into the sponge at the start
- Duration
- 96 hours
- What was measured
- Mast cell degranulation, nerve growth factor, growth of new nerve fibres, sensitivity to touch and inflammatory markers in the nerve root ganglia
What the authors reported
Palmitoylethanolamide reduced mast cell degranulation in a dose-dependent way (p < 0.01 at the highest dose), lowered nerve growth factor, prevented nerve sprouting into the granuloma and reduced touch sensitivity.
Limits of this study
A single rat model at one time point, with local injection rather than a dose by mouth. It is one of the main sources for the mast cell mechanism, and it shows that mechanism in rats, not an effect in patients. Funding was not visible on the page checked.
Source
Entry checked against the full text at the publisher (Springer) on 2026-09-21. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.