Palmitoylethanolamide-Incorporated Elastic Nano-Liposomes for Enhanced Transdermal Delivery and Anti-Inflammation
Laboratory studyHumansOther animalsTopical
- Design
- Laboratory study
- Subjects
- HaCaT human keratinocyte cells; participants in a human skin patch test (number not stated)
- Dose used in the study
- Palmitoylethanolamide loaded into elastic nano-liposomes (PEA-ENL), applied topically
- Duration
- Not stated in the abstract
- What was measured
- Transdermal delivery and skin retention, cytotoxicity in HaCaT cells, allergic reaction in a human skin patch test, cell migration, and expression of genes linked to anti-nociceptive, anti-inflammatory and skin-barrier-repair effects
What the authors reported
PEA-ENL showed efficient transdermal delivery and skin retention with negligible toxicity toward HaCaT cells and no allergic reaction in the human skin patch test. Treatment increased cell migration and changed expression of genes tied to anti-nociceptive, anti-inflammatory and skin-barrier-repair effects.
Limits of this study
A formulation study combining cell testing and a skin patch test; it cannot show effect in treating skin conditions in practice. The authors declare no conflicts of interest.
Source
PubMed 39065574 · doi:10.3390/pharmaceutics16070876
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.