Distribution of Cannabinoid Receptors in Keratinocytes of Healthy Dogs and Dogs With Atopic Dermatitis
Laboratory studyDogs
- Design
- Laboratory study
- Subjects
- Skin samples from 7 healthy dogs and 8 dogs with atopic dermatitis
- Dose used in the study
- Not stated in the abstract; no treatment was given
- Duration
- Not stated in the abstract
- What was measured
- Immunofluorescence for CB1, CB2, GPR55, TRPV1, TRPA1, PPAR-alpha and 5-HT1a receptors in skin keratinocytes, with quantitative scoring.
What the authors reported
Keratinocytes of both healthy and atopic dogs showed all seven receptors. CB2, TRPA1 and 5-HT1a were significantly upregulated in the epidermis of dogs with atopic dermatitis. These receptors, including PPAR-alpha, a palmitoylethanolamide target, are present in canine skin.
Limits of this study
A small tissue study of 15 dogs that measured receptors only; no palmitoylethanolamide or other treatment was tested, so it cannot show effect in dogs treated in practice. The authors declare no commercial or financial relationships.
Source
PubMed 35873682 · doi:10.3389/fvets.2022.915896
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.