Essential fatty acids deficient diet modulates N-Acylethanolamide profile in rat's tissues
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Male rats; numbers not stated in the abstract
- Dose used in the study
- No palmitoylethanolamide was given; a diet lacking essential fatty acids, palmitic and oleic acids, replaced with saturated fat
- Duration
- 12 weeks
- What was measured
- Fatty acid profiles in plasma, liver, adipose tissue and hypothalamus; tissue levels of anandamide, palmitoylethanolamide and oleoylethanolamide; body weight.
What the authors reported
The study found:
- The deficient diet lowered n-3 and n-6 polyunsaturated fats in plasma, liver and adipose tissue and raised oleic and mead acids.
- Anandamide and palmitoylethanolamide fell in liver and brain, while oleoylethanolamide rose in liver and adipose tissue.
- Body weight fell by 50 per cent.
Limits of this study
A rat diet study that measured endogenous palmitoylethanolamide; no PEA was given, so it says nothing about supplementation. It cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 31978675 · doi:10.1016/j.plefa.2020.102053
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.