Palmitoylethanolamide Reduces Neuropsychiatric Behaviors by Restoring Cortical Electrophysiological Activity in a Mouse Model of Mild Traumatic Brain Injury

Francesca Guida, Serena Boccella, Monica Iannotta, Danilo De Gregorio, Catia Giordano, Carmela Belardo, Rosaria Romano, Enza Palazzo, Maria A Scafuro, Nicola Serra, Vito de Novellis, Francesco Rossi, Sabatino Maione, Livio Luongo. Front Pharmacol. 2017 Mar 6;8:95.

Laboratory studyOther animals

Design

Laboratory study

Subjects

Mice with mild traumatic brain injury (mTBI)

Dose used in the study

PEA; dose and route not stated in the abstract

Duration

Behaviour assessed from day 14 (anxiety/aggression) and from day 60 (depressive-like behaviour, social interaction) after mTBI

What was measured

Anxiety, aggression, depressive-like behaviour, social interaction, IL-1beta expression and medial prefrontal cortex neuronal firing.

What the authors reported

PEA reduced the behavioural changes seen in mice with mild traumatic brain injury and partly normalised the biochemical and functional changes. Untreated mTBI mice had developed anxious, aggressive and reckless behaviour by day 14, with depressive-like behaviour and impaired social interaction from day 60, alongside altered IL-1beta and prefrontal cortex neuronal firing.

Limits of this study

A mouse model of mild traumatic brain injury; it cannot show effect in people. Funding and conflicts not stated in the abstract.

Source

PubMed 28321191 · doi:10.3389/fphar.2017.00095

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.