Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis
Laboratory studyDogsOther animals
- Design
- Laboratory study
- Subjects
- Freshly isolated canine keratinocytes, human HaCaT keratinocytes and HEK-293 cells
- Dose used in the study
- Adelmidrol, a PEA analogue, or azelaic acid added to cell cultures
- Duration
- Cell culture
- What was measured
- Endocannabinoid and PEA concentrations; expression of PEA-making and PEA-degrading enzymes; release of the chemokine MCP-2 from stimulated keratinocytes
What the authors reported
Adelmidrol raised PEA concentrations in dog keratinocytes and other cells, without inhibiting the PEA-degrading enzymes, and reduced MCP-2 release. The authors describe this as an entourage effect on the cells' own PEA.
Limits of this study
A cell study of adelmidrol, a related compound used in veterinary skin products, not of PEA given as a supplement. Two authors are from Innovet, which makes adelmidrol products.
Source
PubMed 26639824 · doi:10.1016/j.tvjl.2015.10.060
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.