Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord Injury
Laboratory studyOther animalsWith luteolin
This study tested palmitoylethanolamide together with luteolin. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Mice given a spinal cord injury by vascular clip compression at T5-T8
- Dose used in the study
- Co-ultramicronised PEA and luteolin (co-ultraPEALut), 1 mg/kg given into the abdomen daily for 72 hours after injury
- Duration
- 72 hours of treatment after spinal cord injury
- What was measured
- New neuron formation (bromodeoxyuridine and doublecortin markers), dendritic spine density by Golgi staining, and neurotrophic factors (BDNF, GDNF, nerve growth factor, neurotrophin-3) in the spinal cord
What the authors reported
Co-ultraPEALut increased the numbers of bromodeoxyuridine-positive and doublecortin-positive cells in the injured spinal cord and raised expression of BDNF, GDNF, nerve growth factor and neurotrophin-3. Dendritic spine maturation, assessed by Golgi staining, also increased. The authors read this as evidence for a role of co-ultraPEALut in the survival and differentiation of new neurons after spinal cord injury.
Limits of this study
A mouse model of surgically induced spinal cord injury; it cannot show effect in people. Funding and conflicts not stated in the abstract, though the group has previously worked with Epitech, which makes co-ultramicronised PEA/luteolin.
Source
PubMed 27014061 · doi:10.3389/fphar.2016.00047
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.