Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Rat hepatic stellate cell line (LX-2); rats with carbon tetrachloride-induced liver fibrosis
- Dose used in the study
- In vitro, PEA added to LX-2 cells; in vivo, PEA 20 mg/kg intraperitoneally, three times weekly from week 3
- Duration
- 4-week carbon tetrachloride protocol, with PEA given during weeks 3 and 4
- What was measured
- Hepatic stellate cell activation (alpha-SMA), TGF-beta1/SMAD signalling, fibrotic area, collagen deposition and Kupffer cell activation
What the authors reported
PEA reduced TGF-beta1-induced alpha-SMA expression and SMAD2 phosphorylation in hepatic stellate cells and upregulated SMAD7. In rats, it significantly reduced fibrotic area, type I collagen deposition and activation of hepatic stellate and Kupffer cells.
Limits of this study
A rat and cell-line model of liver fibrosis; it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 30057547 · doi:10.3389/fphar.2018.00709
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.