Ocular Formulation Based on Palmitoylethanolamide-Loaded Nanostructured Lipid Carriers: Technological and Pharmacological Profile
Laboratory studyOther animalsTopical
- Design
- Laboratory study
- Subjects
- Rat eyes given a single instillation of a PEA-loaded nanostructured lipid carrier (NLC) ophthalmic formulation; streptozotocin-induced diabetic rats for the TNF-alpha measurement
- Dose used in the study
- PEA-loaded nanostructured lipid carrier ophthalmic formulation, topical eye instillation
- Duration
- Not stated in the abstract
- What was measured
- Nanoparticle size, homogeneity, surface charge and physical stability; retinal distribution of PEA after instillation; retinal TNF-alpha levels in diabetic rats after topical treatment
What the authors reported
The nanostructured lipid carrier formulation delivered substantial PEA levels to the retina after a single instillation, and significantly reduced retinal TNF-alpha in streptozotocin-induced diabetic rats.
Limits of this study
A formulation and animal-model study; it cannot show effect in people, though the authors state clinical studies are in progress. The authors declare no conflict of interest.
Source
PubMed 32046269 · doi:10.3390/nano10020287
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.