Anti-Inflammatory Effects of Fucoxanthinol in LPS-Induced RAW264.7 Cells through the NAAA-PEA Pathway
Laboratory studyOther animalsWith fucoxanthinol (a seaweed carotenoid that inhibits NAAA and raises cellular PEA, tested alone)
This study tested palmitoylethanolamide together with fucoxanthinol (a seaweed carotenoid that inhibits NAAA and raises cellular PEA, tested alone). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- RAW264.7 mouse macrophage cells stimulated with lipopolysaccharide
- Dose used in the study
- Fucoxanthinol pre-treatment in culture; concentrations not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Binding to and inhibition of NAAA; cellular PEA levels; mRNA for iNOS, IL-6 and TNF-alpha; production of TNF-alpha, IL-6, IL-1-beta and nitric oxide; effect of the PPAR-alpha antagonist GW6471.
What the authors reported
This laboratory study found:
- Fucoxanthinol bound the NAAA active site and inhibited the enzyme.
- It reversed the LPS-induced fall in PEA, reduced inflammatory mRNA and cut TNF-alpha, IL-6, IL-1-beta and nitric oxide production.
- The PPAR-alpha antagonist GW6471 abolished the effect on nitric oxide.
Limits of this study
A mouse cell line study; it cannot show effect in people or animals treated in practice. PEA was not administered. The authors declare no conflict of interest.
Source
PubMed 32326173 · doi:10.3390/md18040222
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.