Micronized palmitoylethanolamide reduces joint pain and glial cell activation

Maria Lavinia Bartolucci, Ida Marini, Francesco Bortolotti, Daniela Impellizzeri, Rosanna Di Paola, Giuseppe Bruschetta, Rosalia Crupi, Marco Portelli, Angela Militi, Giacomo Oteri, Emanuela Esposito, Salvatore Cuzzocrea. Inflamm Res. 2018 Oct;67(10):891-901.

Laboratory studyOther animals

Design

Laboratory study

Subjects

Rats with complete Freund's adjuvant (CFA)-induced temporomandibular joint (TMJ) inflammation

Dose used in the study

micronised PEA (m-PEA) 10 mg/kg or vehicle, given 1 hour after CFA injection

Duration

Assessed at 24 and 72 hours after CFA injection

What was measured

TMJ edema, mechanical allodynia, satellite glial cell activation (GFAP) and macrophage activation (Iba1) in the trigeminal ganglion.

What the authors reported

CFA-injected animals showed TMJ edema and mechanical allodynia along with increased GFAP-positive satellite glial cells and macrophage activation in the trigeminal ganglion. Micronised PEA significantly reduced TMJ damage and pain, and reduced macrophage activation and Iba1 upregulation.

Limits of this study

A rat model of TMJ inflammation; it cannot show effect in people. Funding and conflicts not stated in the abstract.

Source

PubMed 30121836 · doi:10.1007/s00011-018-1179-y

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.