G protein-coupled receptor 55 activated by palmitoylethanolamide is associated with the development of nocturia associated with circadian rhythm disorders
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Male C57BL/6 mice and primary cultured mouse urothelial cells
- Dose used in the study
- Not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- GPR55 localisation in bladder, PEA-induced calcium signalling and NGF and PGI2 release in urothelial cells, and activation of the micturition reflex pathway after PEA.
What the authors reported
GPR55 was mainly in the urothelial layer. PEA triggered calcium release from the endoplasmic reticulum in urothelial cells and release of NGF and PGI2, which stimulated the pontine micturition centre and induced nocturia in mice. The authors propose that high blood PEA during the sleep phase, seen with clock gene abnormalities, drives nocturia through GPR55.
Limits of this study
A mouse and cell study; it cannot show effect in people. It describes PEA as a possible cause of nocturia, not a treatment. Doses and route are not in the abstract. The authors declare no conflict of interest.
Source
PubMed 37704067 · doi:10.1016/j.lfs.2023.122072
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.