Relationship Between Circulating Fatty Acids and Fatty Acid Ethanolamide Levels After a Single 2-h Dietary Fat Feeding in Male Sprague-Dawley Rats : Elevated levels of oleoylethanolamide, palmitoylethanolamide, linoleoylethanolamide, arachidonoylethanolamide and docosahexanoylethanolamide after a single 2 h dietary fat feeding in male Sprague Dawley rats
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- 64 male Sprague-Dawley rats fed safflower oil (control), canola oil (CO), or DHA-rich oil (DRO)
- Dose used in the study
- Not applicable; a single dietary fat bolus of 40% of energy given within a 2-hour window, not a PEA treatment
- Duration
- Fatty acid ethanolamide levels measured at 3, 6, 12 and 24 hours after feeding
- What was measured
- Plasma and tissue levels of fatty acid ethanolamides (OEA, PEA, linoleoylethanolamide, anandamide, DHEA) after dietary fat feeding, in 64 rats fed safflower oil, canola oil or DHA-rich oil.
What the authors reported
Levels of each ethanolamide changed over time in patterns specific to the compound and fat type. At 3 hours, plasma and liver OEA were higher with 95% canola:5% DHA-rich oil; at 12 hours, plasma PEA was lower with 50:50 canola:DHA-rich oil than with 95% canola oil; and plasma DEA rose only after 24 hours, dose-dependently.
Limits of this study
A rat feeding study measuring endogenous ethanolamide levels, not a PEA treatment; it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 29032410 · doi:10.1007/s11745-017-4293-7
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.