Relationship Between Circulating Fatty Acids and Fatty Acid Ethanolamide Levels After a Single 2-h Dietary Fat Feeding in Male Sprague-Dawley Rats : Elevated levels of oleoylethanolamide, palmitoylethanolamide, linoleoylethanolamide, arachidonoylethanolamide and docosahexanoylethanolamide after a single 2 h dietary fat feeding in male Sprague Dawley rats
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- 64 male Sprague-Dawley rats fed safflower oil (control), canola oil (CO), or DHA-rich oil (DRO)
- Dose used in the study
- Not applicable; a single dietary fat bolus of 40% of energy given within a 2-hour window, not a PEA treatment
- Duration
- Fatty acid ethanolamide levels measured at 3, 6, 12 and 24 hours after feeding
- What was measured
- Plasma and tissue levels of fatty acid ethanolamides (OEA, PEA, linoleoylethanolamide, anandamide, DHEA) after dietary fat feeding
What the authors reported
Levels of each ethanolamide changed over time in patterns specific to the compound and fat type. At 3 hours, plasma and liver OEA were higher with 95% canola:5% DHA-rich oil; at 12 hours, plasma PEA was lower with 50:50 canola:DHA-rich oil than with 95% canola oil; and plasma DEA rose only after 24 hours, dose-dependently.
Limits of this study
A rat feeding study measuring endogenous ethanolamide levels, not a PEA treatment; it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 29032410 · doi:10.1007/s11745-017-4293-7
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.