Palmitoylethanolamide Promotes White-to-Beige Conversion and Metabolic Reprogramming of Adipocytes: Contribution of PPAR-α
Laboratory studyHumansOther animals
- Design
- Laboratory study
- Subjects
- Young male C57Bl/6J mice fed a control or high-fat diet; mature 3T3-L1 mouse adipocytes; human adipose-derived stromal cells from normal-weight and obese patients
- Dose used in the study
- Ultramicronised palmitoylethanolamide 30 mg/kg/day orally for 7 weeks, added to 12 weeks of high-fat diet
- Duration
- 7 weeks of treatment, following 12 weeks of high-fat diet
- What was measured
- Brown and beige adipose tissue morphology and thermogenic gene expression, leptin signalling, mitochondrial bioenergetics, AMPK phosphorylation, and adipogenic differentiation in human adipose-derived stromal cells, using the PPAR-alpha antagonist GW6471.
What the authors reported
This lab study found:
- Palmitoylethanolamide restored brown fat morphology and function, increased UCP1 positivity and noradrenergic innervation, and induced thermogenic gene transcription.
- It promoted beige conversion of white fat, restored leptin signalling and tissue hormone sensitivity, and improved mitochondrial bioenergetics and increased AMPK phosphorylation in adipocytes.
- It also increased adipogenic differentiation and AMPK phosphorylation in human stromal cells.
- The PPAR-alpha antagonist GW6471 blocked these effects.
Limits of this study
A mouse and cell study of diet-induced obesity; it cannot show effect in people with obesity. The authors declare no conflict of interest.
Source
PubMed 35214069 · doi:10.3390/pharmaceutics14020338
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.