Palmitoylethanolamide Ameliorates Hippocampal Damage and Behavioral Dysfunction After Perinatal Asphyxia in the Immature Rat Brain
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Newborn Sprague Dawley rats subjected to perinatal asphyxia (water-bath model)
- Dose used in the study
- PEA 10 mg/kg, given within the first hour of life
- Duration
- Assessed 1 month after the asphyxia insult
- What was measured
- Hippocampal neuronal damage (electron microscopy, immunohistochemistry, western blot) and behaviour (Open Field, Passive Avoidance, Elevated Plus Maze). PEA (10 mg/kg) was given within the first hour of life.
What the authors reported
Perinatal asphyxia caused CA1 neuronal degeneration, higher phosphorylated neurofilament and lower MAP-2 in the CA1 area, with vertical exploration impairment and anxiety-related behaviour. PEA treatment lessened the hippocampal damage and the behavioural changes caused by perinatal asphyxia.
Limits of this study
A neonatal rat model of perinatal asphyxia; it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 29662433 · doi:10.3389/fnins.2018.00145
Entry checked against the abstract on PubMed on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.