Effect of palmitoylethanolamide on inflammatory and neuropathic pain in rats
Laboratory studyOther animals
- Design
- Laboratory study
- Subjects
- Male Sprague-Dawley rats with spinal nerve transection (neuropathic pain) or intra-articular monoiodoacetic acid (inflammatory pain)
- Dose used in the study
- PEA given by intraperitoneal and intra-articular injection; exact dose not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Mechanical and cold sensitivity (von Frey filaments, acetone test) and paw withdrawal responses
What the authors reported
Spinal nerve transection lowered the mechanical threshold and raised the frequency of response to acetone. PEA, by intraperitoneal and intra-articular injection, significantly reduced mechanical hyperalgesia from chronic inflammation. The authors conclude PEA may relieve inflammatory and neuropathic pain, especially pain from mechanical hyperalgesia, but not cold allodynia.
Limits of this study
Rat models of neuropathic and inflammatory pain; it cannot show effect in people. Funding and conflicts not stated in the abstract.
Source
PubMed 29046777 · doi:10.4097/kjae.2017.70.5.561
Entry checked against the abstract on PubMed on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.