Fatty Acid Amides Synthesized from Andiroba Oil (Carapa guianensis Aublet.) Exhibit Anticonvulsant Action with Modulation on GABA-A Receptor in Mice: A Putative Therapeutic Option
Laboratory studyOther animalsWith fatty acid amides FAA1 and FAA2 synthesised from andiroba oil (tested alone; not palmitoylethanolamide itself)
This study tested palmitoylethanolamide together with fatty acid amides FAA1 and FAA2 synthesised from andiroba oil (tested alone; not palmitoylethanolamide itself). Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.
- Design
- Laboratory study
- Subjects
- Mice with pentylenetetrazole-induced seizures (numbers not stated in the abstract)
- Dose used in the study
- FAA1 and FAA2 from Carapa guianensis oil; dose and route not stated in the abstract
- Duration
- Not stated in the abstract
- What was measured
- Latency to first myoclonic jerk, duration of tonic-clonic seizures, electrocorticography, and reversal by the benzodiazepine antagonist flumazenil
What the authors reported
This laboratory study found:
- Only FAA1 increased latency to the first myoclonic jerk and reduced total tonic-clonic seizure duration compared with the PTZ model.
- FAA1 reduced PTZ-induced electrocortical changes, lowering beta-rhythm amplitude and energy.
- Flumazenil reversed the effect, pointing to the benzodiazepine site of GABA-A receptors.
Limits of this study
A mouse seizure model of plant-derived fatty acid amides, not palmitoylethanolamide; it cannot show effect in people. The abstract does not name the amides' structures. The authors declare no conflicts of interest.
Source
PubMed 32164340 · doi:10.3390/ph13030043
Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.