Administration of palmitoylethanolamide in combination with topiramate in the preventive treatment of nummular headache

Domenico Chirchiglia, Attilio Della Torre, Francesco Signorelli, Giorgio Volpentesta, Giusy Guzzi, Carmelino Angelo Stroscio, Federica Deodato, Donatella Gabriele, Angelo Lavano. Int Med Case Rep J. 2016 Jul 18;9:193-5.

Case seriesHumansWith topiramate

This study tested palmitoylethanolamide together with topiramate. Its results cannot be assigned to palmitoylethanolamide alone. More combination studies.

Design

Case series

Subjects

1 patient, a 57-year-old woman, with nummular headache

Dose used in the study

Standard oral doses of palmitoylethanolamide and topiramate, given in combination

Duration

Not stated in the abstract

What was measured

Pain symptoms and pain-measuring scale scores in preventive treatment of nummular headache

What the authors reported

Combined oral PEA and topiramate improved the patient's pain symptoms and pain scale scores.

Limits of this study

A single case report; it cannot show whether PEA added anything beyond topiramate alone, or whether the result applies to other patients. Funding and conflicts not stated in the abstract.

Source

PubMed 27486344 · doi:10.2147/IMCRJ.S106323

Entry checked against the abstract on PubMed on 2026-09-22. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.